Results 51 to 60 of about 19,332,303 (287)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Gauge theory formulation of hyperbolic gravity
Journal of High Energy Physics, 2021 We formulate the most general gravitational models with constant negative curvature (“hyperbolic gravity”) on an arbitrary orientable two-dimensional surface of genus g with b circle boundaries in terms of a PSL(2, ℝ) ∂ gauge theory of flat connections ...
Frank Ferrari
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Scale invariance beyond criticality within the mean-field analysis of tensorial field theories
Journal of High Energy PhysicsWe continue the series of articles on the application of Landau-Ginzburg mean-field theory to unveil the basic phase structure of tensorial field theories which are characterized by combinatorially non-local interactions.
Roukaya Dekhil +3 more
doaj +1 more source
Resonance-based schemes for dispersive equations via decorated trees
Forum of Mathematics, Pi, 2022 We introduce a numerical framework for dispersive equations embedding their underlying resonance structure into the discretisation. This will allow us to resolve the nonlinear oscillations of the partial differential equation (PDE) and to approximate ...
Yvain Bruned, Katharina Schratz
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Finite-size local dimension as a tool or extracting geometrical properties of attractors of dynamical systems [PDF]
Nonlinear Processes in GeophysicsLocal dimension computed using extreme value theory (EVT) is usually used as a tool to infer dynamical properties of a given state ζ of the chaotic attractor of the system.
M. Bonte, S. Vannitsem
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Nonlocal vertices and analyticity: Landau equations and general Cutkosky rule
Journal of High Energy Physics, 2018 We study the analyticity properties of amplitudes in theories with nonlocal vertices of the type occurring in string field theory and a wide class of nonlocal field theory models.
Paokuan Chin, E. T. Tomboulis
doaj +1 more source