Results 51 to 60 of about 89,439 (293)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Class field theory, Hasse principles and Picard-Brauer duality for two-dimensional local rings
, 2023 We draw concrete consequences from our arithmetic duality for two-dimensional local rings with perfect residue field. These consequences include class field theory, Hasse principles for coverings and $K_{2}$ and a duality between divisor class groups and
Suzuki, Takashi
core +1 more source
Tame class field theory over local fields
, 2022 Substantial revision, 68 pages. A version of this paper is accepted to appear in Amer.
Gupta, Rahul +2 more
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Finite-size local dimension as a tool or extracting geometrical properties of attractors of dynamical systems [PDF]
Nonlinear Processes in GeophysicsLocal dimension computed using extreme value theory (EVT) is usually used as a tool to infer dynamical properties of a given state ζ of the chaotic attractor of the system.
M. Bonte, S. Vannitsem
doaj +1 more source
Integrable matrix models in discrete space-time
SciPost Physics, 2020 We introduce a class of integrable dynamical systems of interacting classical matrix-valued fields propagating on a discrete space-time lattice, realized as many-body circuits built from elementary symplectic two-body maps.
Žiga Krajnik, Enej Ilievski, Tomaž Prosen
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Exact Solutions in Poincaré Gauge Gravity Theory
Universe, 2019 In the framework of the gauge theory based on the Poincaré symmetry group, the gravitational field is described in terms of the coframe and the local Lorentz connection. Considered as gauge field potentials, they give rise to the corresponding field
Yuri N. Obukhov
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source