Results 61 to 70 of about 89,439 (293)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

A Note on Tamely Ramified Class Field Theory of Two Dimensional Local Rings

open access: yes, 2022
In this note, we treat two dimensional complete local rings which are called "semi-stable local rings" and discuss the tame class filed theory. In 1987, Professor S.
Ishida, Shinji
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Violation of causality in f(T) gravity

open access: yesEuropean Physical Journal C: Particles and Fields, 2017
In the standard formulation, the f(T) field equations are not invariant under local Lorentz transformations, and thus the theory does not inherit the causal structure of special relativity.
G. Otalora, M. J. Rebouças
doaj   +1 more source

Locality and causality properties of light cone string field theory [PDF]

open access: yes, 2004
The recent discovery of a new maximally supersymmetric background for the type IIB superstring theory has revived the interest in light cone string field theory.
Kyritisis, Konstantinos
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

The Field of Norms Functor and the Hilbert Symbol [PDF]

open access: yes, 2010
The classical Hilbert symbol of a higher local field $F$ containing a primitive $p^M$-th root of unity $\zeta_M$ is a pairing $F^*/(F^*)^{p^M}\times K_N(F)/p^M \to \mu_{p^M}$, describing Kummer extensions of exponent $p^M$.
JENNI, RUTH,CHRISTINE   +1 more
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Spin-locality of higher-spin theories and star-product functional classes

open access: yesJournal of High Energy Physics, 2020
The analysis of spin-locality of higher-spin gauge theory is formulated in terms of star-product functional classes appropriate for the β → −∞ limiting shifted homotopy proposed recently in [1] where all ω 2 C 2 higher-spin vertices were shown to be spin-
O. A. Gelfond, M. A. Vasiliev
doaj   +1 more source

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