Results 71 to 80 of about 1,432,258 (269)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Local content of bipartite qubit correlations

Physical Review A, 2010
One of the last open problems concerning two qubits in a pure state is to find the exact local content of their correlation, in the sense of Elitzur, Popescu and Rohrlich (EPR2) [Phys. Lett. A 162, 25 (1992)]. We propose a new EPR2 decomposition that allows us to prove, for a wide range of states psi(theta)=cos(theta)|00>+sin(theta)|11>, that ...
Branciard, Cyril, Gisin, Nicolas, Scarani, Valerio   +2 more
openaire   +7 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Sustainability, Corporate Community Engagement and Enterprise Development – Lessons from a Case Study in Emu-Ebendo Niger-Delta, Nigeria

Problemy Ekorozwoju, 2017
Corporate community engagement remains an under researched area in sustainability debates.  Presenting a case study, based on in-depth interviews and site visits, of how one indigenous company Energia Ltd has formed a strong partnership or bond with the
O.E. Ajide, P.A. Strachan, A. Russell, D.R. Jones   +3 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Local Queuing Under Contention.

, 2018
We study stability of local packet scheduling policies in a distributed system of n nodes. The local policies at nodes may only access their local queues, and have no other feedback from the underlying distributed system. The packets arrive at queues according to arrival patterns controlled by an adversary restricted only by injection rate rho and ...
Pawel Garncarek, Tomasz Jurdzinski, Dariusz R. Kowalski   +2 more
openaire   +3 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Local content in Brazil: conceptual framework and methodological implications

Digithum, 2009
This article presents work in progress from PhD research investigating the use of the internet in the favelas (shantytowns) of Rio de Janeiro, Brazil, with a particular focus on the internet content produced and shared by those who live there.
Tori Holmes
doaj  

Development of Website-Based Digital Teaching Materials for the Jarimatika Qur'an Method: A Local Content Integration Approach

Tarbawi
This study employs a research and development approach to identify the need, design, validity, practicality, and effectiveness of website-based digital teaching materials for the Jarimatika Qur'an Method as local content.
Rizki Muthmainnah Amir, Arismunandar Arismunandar, Nurhikmah H   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source