Results 91 to 100 of about 1,005,615 (312)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Creation of Local Culture by the Local Government in Japan

, 1992
application/pdfThere are few of example that creation of local culture in small cities in Japan is being developed as a policy, and Nakaniida town is positioned as a pioneer among other cities.
後藤, 春彦, Goto, Haruhiko
core  

La re-politisation des politiques culturelles locales en France. À propos des affaires médiatiques entre élus locaux et professionnels de la culture

, 2009
En France, depuis le début des années 1990, des « affaires » médiatiques en nombre inédit révèlent une conflictualité croissante entre agents politiques locaux et professionnels de la culture, s’opposant notamment sur les formes et les finalités ...
Matz, Kevin
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Local Culture and Community Through a Digital Lens: Viewpoint on Designing and Implementing a Virtual Second Look Event for Residency Applicants. [PDF]

JMIR Med Educ, 2023
Martindale JM, Carrasquillo RA, Otallah SI, Brooks AK, Denizard-Thompson N, Pharr E, Choate N, Sokolosky M, Strauss LD.   +8 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The Practice and Inheriting of the Bai People’s local Culture of Dali

, 2015
This paper discusses the status quo and problems of the local cultural heritage of ethnic minorities in the southwest China, which is in the context of modernization. The data in this paper are obtained through long-term field work.
LI, Xiufang
core   +2 more sources

Study of nonsynchronous online teaching of regional anatomy for international students integrated with medical humanities and local culture during COVID-19 pandemic. [PDF]

Surg Radiol Anat, 2023
Hao Y, Ding H, Li Q, Lin M, Ibrahim A, Wang X, Wu Y, Leng S.   +7 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Assistance to the Majelis Taklim Based on Religious Moderation as an Effort to Form Adaptive Behavior of Minority Muslims with Local Culture in the Tengger Tribal Region

Jurnal Soeropati
The existence of the taklim assembly has an important role in the socialization and enculturation process to enable Muslims to survive in a society that is predominantly Hindu.
Ahmad Marzuki, Askhabul Kirom, Achmad Yusuf   +2 more
doaj   +1 more source