Results 41 to 50 of about 853,609 (266)

Unmet needs of ambulatory cancer patients undergoing cancer treatments in a Portuguese hospital: a cross-sectional study

BMC Palliative Care
Background Patients with cancer experience a variety of needs at every stage of their illness. Many of these needs can be addressed with palliative care. Cancer patients’ palliative needs should therefore be proactively identified and managed. This study
Filipa Simões, Ana Fortuna, Joana Magalhães, Giovanni Cerullo, Manuel Luís Capelas, José Luís Pereira   +5 more
doaj   +1 more source

Mainstreaming sustainable consumption: lessons learned from a four-year research program

Sustainability: Science, Practice, & Policy
This Brief Report describes the research and key lessons learned in the initial four-year phase of the research program Mistra Sustainable Consumption that seeks to stimulate a transition to more sustainable consumption in Sweden.
Åsa Svenfelt, Karin Bradley
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Kearifan Lokal Masyarakat Kabupaten Madiun Dalam Menyikapi Pandemi Covid-19

Jurnal Antropologi: Isu-Isu Sosial Budaya, 2021
Covid-19 pandemic has caused massive and widespread fear from various walks of life. The Covid-19 outbreak has affected all aspects of human life. This social reality encourages the people of Madiun Regency to make an effort to respond the pandemic by ...
Muhammad Hanif
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Lembar Kerja Siswa Berbasis Budaya Lokal Ngada Untuk Pembelajaran Tematik Siswa Sekolah Dasar

Jurnal Pendidikan Dasar Nusantara, 2020
Recent instructions has been focusing on critical thinking skills by utilizing contextual learning resources. Therefore, this study was conducted by aiming at describing the quality of local culture-based students’ worksheet from the aspect of content ...
Dek Ngurah Laba Laksana, Yosefina Uge Lawe, Frumensia Ripo, Maria Oliva Bolo, Tarsisius Donbosko Dua   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Development of A Basic English Board Game on Local Culture as An Interactive Learning Media for Elementary Students in Rural Papua

Jurnal Kependidikan
This study aims to develop a board game as an interactive English learning media for elementary school students in rural Papua. At the elementary level, English has been mandated as a compulsory subject; however, interest and motivation to learn remain ...
Marni Bawawa, Ratna Purwanti, Sri Ananda Pertiwi   +2 more
doaj   +1 more source