Results 51 to 60 of about 853,609 (266)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Sickness Absence and Local Cultures [PDF]
, 2010 Sickness absence has been found to vary substantially across geographical areas. There are large differences between different countries but also between different regions within a particular country. In the literature some of these observed differentials have been suggested to stem from differences in local norms with regard to the legitimacy of ...
Ekblad, Kristin, Bokenblom, Mattias
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Pembelajaran Lingkungan Berbasis Kearifan Lokal dengan Model Experiential Learning
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2019 : Environmental damage that occurs on earth is caused by human activities. Human activities that use the environment excessively cause the environment to be damaged.
Bunga Dwi Immaniar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2019 : The purpose of this development research is to produce explanatory text teaching materials based on local wisdom of East Nusa Tenggara for class XI students. Local wisdom-based teaching materials can be used as a source of learning.
Petronela Mau +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Menuju Pembangunan Partisipatif (bagaimana Mendayagunakan Kebudayaan Lokal)
JKAP (Jurnal Kebijakan dan Administrasi Publik), 2015 Grassroot people are development actors who determine course of development so that it will bring about a more valuable change. That is the basic argument as why people autonomy and participation are the keywords for the development achievement. Research
Irwan Abdullah
doaj +1 more source
Agama, Etnisitas dan Perdamaian di Pulau Enggano Provinsi Bengkulu
Hanifiya, 2020 This article explores the diversity of ethnicities and religions in the Engganese society, which has become color in their life dynamics—local wisdom based on customary rules succeeded in uniting differences into peace.
Intan Permata Sari
doaj +1 more source