Results 61 to 70 of about 10,289,866 (260)
Jurnal KependidikanThis study aims to develop a board game as an interactive English learning media for elementary school students in rural Papua. At the elementary level, English has been mandated as a compulsory subject; however, interest and motivation to learn remain ...
Marni Bawawa +2 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
States and Local Legal Cultures in Medieval Islam: A comparative study of Akbar’s Mughal Rule and Sultan Agung’s Mataram in 16th and 17th Century [PDF]
, 2016 This study seeks to expand the horizon of existing literatures on the dialectic of religion, legal culture and local dynamics by comparing two great Muslim rulers in two different parts of the world in the first Islamic millennium: Mughal Emperor Akbar ...
Achmad, Noor +3 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Pembelajaran Lingkungan Berbasis Kearifan Lokal dengan Model Experiential Learning
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2019 : Environmental damage that occurs on earth is caused by human activities. Human activities that use the environment excessively cause the environment to be damaged.
Bunga Dwi Immaniar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Local Activism: Changing Culture Norms
, 2021 Child marriage, though internationally recognized as a human rights violation, is a common culture norm in many traditional societies around the world.
Pattee, Isabel
core
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2019 : The purpose of this development research is to produce explanatory text teaching materials based on local wisdom of East Nusa Tenggara for class XI students. Local wisdom-based teaching materials can be used as a source of learning.
Petronela Mau +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source