Results 81 to 90 of about 10,289,866 (260)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Designing Culturally Responsive Education Strategies to Cultivate Young Children's Cultural Identities: A Case Study of the Development of a Preschool Local Culture Curriculum. [PDF]
Children (Basel), 2022 Shih YH.
europepmc +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
The Creation of Local Culture by the Local Government in Japan
, 1992 application/pdfThere are few of example that creation of local culture in small cities in Japan is being developed as a policy, and Nakaniida town is positioned as a pioneer among other cities.
後藤, 春彦, Goto, Haruhiko
core
Study of nonsynchronous online teaching of regional anatomy for international students integrated with medical humanities and local culture during COVID-19 pandemic. [PDF]
Surg Radiol Anat, 2023 Hao Y +7 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Positioning Culture within Canadian Municipalities
, 2019 Although sometimes still referred to as ‘creatures of the province’, municipalities in Canada now shape their own policies in a number of complex areas. This includes culture, since municipal cultural planning has broadened the municipal role.
Jeannotte, Sharon +2 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Rethinking Culture and Cultural Analysis
, 2013 The texts in this collection are revised versions of presentations given at the Coimbra International Conference on the Semantics of Culture emph Why ``Culture''?, held on November 24-25, 2011.
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source