Results 71 to 80 of about 8,930,794 (288)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Stygmatyzacja osób uzależnionych od alkoholu oraz systemu leczenia uzależnień w Warszawie i w społeczności lokalnej

Alcoholism and Drug Addiction, 2015
Introduction: Alcoholism is mentioned as one of the most important social problems, and alcohol dependent persons are socially excluded and stigmatised.
Łukasz Wieczorek
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Modeling method of local financial dependence: Evidence from Mongolia

Heliyon
Many countries have been striving to equalize the balance between the central government and sub-government financial disparities without considering political interference.
Ankhbayar Chuluunbaatar, Batjargal Nadmid, Bolormaa Budjav, Wing-Keung Wong   +3 more
doaj   +1 more source

Decomposing Intraday Dependence in Currency Markets: Evidence from the AUD/USD Spot Market

, 2004
The local Hurst exponent, a measure employed to detect the presence of dependence in a time series, may also be used to investigate the source of intraday variation observed in the returns in foreign exchange markets.
Abry, Ambrose, Andersen, Barkoulas, Batten, Batten, Batten, Bollerslev, Bollerslev, Cajueiro, Cajueiro, Cajueiro, Cajueiro, Cheung, Costa, Fama, Geweke, Goodhart, Goodhart, Goodhart, Grau-Carles, Hosking, Hosoya, Hurst, Lo, Lyons, Mandelbrot, Mandelbrot, Mandelbrot, Mandelbrot, Mandelbrot, Matos, Muller, Opong, Teverovsky, Tucker, Van De Gucht   +36 more
core   +2 more sources

The metaphysics of Machian frame-dragging [PDF]

, 2019
The paper investigates the kind of dependence relation that best portrays Machian frame-dragging in general relativity. The question is tricky because frame-dragging relates local inertial frames to distant distributions of matter in a time-independent ...
A Wilson, C Everitt, C Hoefer, D Brill, E Curiel, H Pfister, H Pfister, I Ciufolini, J Schaffer, L Lindblom, V Lam   +10 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Effects and Detectability of Quasi-Single Field Inflation in the Large-Scale Structure and Cosmic Microwave Background

, 2012
Quasi-single field inflation predicts a peculiar momentum dependence in the squeezed limit of the primordial bispectrum which smoothly interpolates between the local and equilateral models.
A. Orsi ., A. Pillepich, A. Slosar, A. Slosar, A.A. Starobinskii, A.P. Yadav, A.P. Yadav ., C. Carbone, C. Carbone, C. Wagner, C. Wagner, C.T. Byrnes, D. Figueroa, D. Jeong, E. Komatsu ., E. Sefusatti, E. Sefusatti, E. Sefusatti, E. Sefusatti, E.P.S Shellard, Emiliano Sefusatti, G.T. Richards ., I. Agullo, J. Fergusson, J. Norena, J.-Q. Xia, J.-Q. Xia ., J.J. Condon ., J.L. Tinker ., James R Fergusson, L. Senatore, L. Verde, M. LoVerde, M. LoVerde, M. Maggiore, M. Pietroni, N. Bartolo, P. Creminelli, Planck collaboration, R. Laureijs ., R. Scoccimarro, S. Cole, S. Matarrese, S. Shandera, T. Baldauf, T. Baldauf, T. Giannantonio, T. Nishimichi, V. Assassi, V. Desjacques, WMAP collaboration, X. Chen, X. Chen, Xingang Chen   +53 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source