Results 151 to 160 of about 75,363 (311)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

2-local derivations on Virasoro algebras

open access: yes, 2019
The present paper is devoted to study 2-local derivations on infinite-dimensional Lie algebras over a field of characteristic zero. We show that every derivation on Virasoro algebra is inner and prove that all 2-local derivations on this algebra is a ...
Yusupov, Bakhtiyor, Ayupov, Shavkat
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Automated derivation of global authorizations for database federations

open access: yes, 1997
Global authorizations in database federations can be derived from local authorizations exported by the databases composing the federation. Particularly, when several component databases participate in the federation and a high number of users and ...
M. Fugini   +2 more
core   +1 more source

Localization theory for derivators

open access: yes, 2018
We outline the theory of reflections for prederivators, derivators and stable derivators. In order to parallel the classical theory valid for categories, we outline how reflections can be equivalently described as categories of fractions, reflective factorization systems, and categories of algebras for idempotent monads.
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Local mappings of operator algebras

open access: yes, 1993
Vita.Local derivations and automorphisms on operator algebras have been investigated in recent papers of Kadison, and Larson-Sourour. A local derivation is a (norm continuous) linear map from an operator algebra A into an A-bimodule M so that for each
Crist, Randall Lee
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Landau–Lifshitz damping from Lindbladian dissipation in quantum magnets

open access: yesNew Journal of Physics
As of now, the phenomenological classical Landau–Lifshitz (LL) damping of magnetic order is linked to a quantum theory of dissipation of Lindbladian form only in sophisticated systems via complicated calculations in certain limits. This is unsatisfactory
Götz S Uhrig
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

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