Results 61 to 70 of about 950,808 (264)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Jurnal Ekonomi dan BisnisThis research focuses on the critical challenges and strategies in developing sustainable tourism in the Jambi Province Heritage Site area by involving the active participation of local communities.
Fitriaty Fitriaty +6 more
doaj +1 more source
THE CONTRIBUTION OF TOURISM MARKETING STRATEGIES TO ECONOMIC DEVELOPMENT AND THE PROMOTION OF LOCAL IDENTITY [PDF]
EconomicaTourism represents a multifunctional economic activity, reflecting the dynamism, adaptability, and efficiency of a modern economy. The tourism system, composed of tourists, economic agents, and tourist destinations, operates through a complex ...
Adrian BULICAN, Elena TURCOV
doaj +1 more source
Strategies for Local Low-Carbon Development
, 2012 E RNEST O RLANDO L AWRENCE B ERKELEY N ATIONAL L ABORATORY Strategies for Local Low-Carbon Development Nan Zhou, Lynn Price, David Fridley, Stephanie Ohshita, Nina Khanna Lawrence Berkeley National Laboratory Hu Min Energy Foundation Hu Xiulian Energy Research Institute November 2012 This work was supported by the Energy Foundation’s China Sustainable ...
Nan Zhou +6 more
openaire +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Promoting Gastronomic Tourism to Foster Local Development: The Stakehodelrs’ Perspective
Almatourism, 2015 The purpose of this study is to highlight the potential of gastronomic tourism as a mechanism for local development by examining stakeholders’ perceptions and the specific actions being carried out at a range of levels in Catalonia. The study reports the
Maria del Pilar Leal Londoño
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source