Mendelianization: Concentrating Polygenic Signal Into a Single Causal Locus
ABSTRACT Complex disorders such as depression and alcohol use involve numerous genetic variants, and implicated loci continue to grow with sample size. This proliferation hampers interpretability, as the mechanisms by which so many variants jointly contribute to pathophysiology remain unclear.
Eric V. Strobl
wiley +1 more source
Distribution network insulator detection based on improved ant colony algorithm and deep learning for UAV. [PDF]
Zhou Y, Zhang D, Ma X.
europepmc +1 more source
Neuromorphic hardware enables the integration of sensing, memory, and computing for intelligent artificial perception. Recent advances in multimodal fusion further highlight its potential for embodied intelligence and next‐generation human–machine interfaces.
Yixin Zhu +3 more
wiley +1 more source
Mapping of 10-km daily diffuse solar radiation across China from reanalysis data and a Machine-Learning method. [PDF]
Qi Q +7 more
europepmc +1 more source
Metrological and Algorithmic Traceability of Machine Learning in Laboratory Medicine
Machine learning is increasingly used in clinical laboratory medicine for test interpretation, outcome prediction, and laboratory operations, but its safe implementation requires traceability that covers both measurement science and data‐driven computation.
Qing Li, Mario Plebani
wiley +1 more source
NSF is required for diverse endocytic modes by promoting fusion and fission pore closure in secretory cells. [PDF]
Wu XS +11 more
europepmc +1 more source
Femoral Skeletal Growth in Early Infancy Assessed by Radiofrequency Echographic Multi‐Spectrometry
Radiofrequency echographic multi‐spectrometry (REMS) acquisition of raw ultrasound radiofrequency signals from neonatal bone. Signals undergo preprocessing and frequency‐domain analysis to extract spectral features reflecting bone properties. A software‐guided procedure then identifies and selects standardized regions of interest (ROIs).
Serafina Perrone +10 more
wiley +1 more source
This prospective study evaluated envafolimab plus chemotherapy in 29 SCLC patients with liver metastases, integrating multi‐omics analyses (WES, RNA‐seq, DNA methylation, ctDNA, and cfDNA methylation). The research framework encompassed granulocyte turnover dynamics, prognostic risk modeling, molecular mechanism exploration across risk strata, and ...
Ning Tang +11 more
wiley +1 more source
GABAergic TH2 Amacrine Cells Participate in Spontaneous Wave Activity in the Developing Retina
Individual TH2 amacrine cells (TH2‐ACs) exhibited spontaneous rhythmic depolarizations during the first and second postnatal weeks, driven by cholinergic starburst amacrine cells (SACs) and glutamatergic bipolar cells (BCs), respectively. Calcium imaging further revealed that these spontaneous depolarizations propagate across the TH2‐AC network in a ...
Wenqiu Wang +6 more
wiley +1 more source
SSP-MambaNet: An automated system for detection and counting of missing seedlings in glass greenhouse-grown virus-free strawberry. [PDF]
Yuan M, Wang D, Lin J, Yang S, Ning J.
europepmc +1 more source

