Results 171 to 180 of about 1,555,406 (315)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

Drilling for oil and gas in New Zealand: environmental oversight and regulation [PDF]

open access: yes, 2014
This report analyses the complex system of laws, agencies, and processes that regulate New Zealand\u27s oil and gas industry. Introduction In part due to the technique of hydraulic fracturing or ‘fracking’, more wells are being drilled in Taranaki and ...
Parliamentary Commissioner for the Environment
core  

The Influence of a Changing Local Environment during Photoinduced CO2 Dissociation. [PDF]

open access: yesAngew Chem Int Ed Engl, 2021
Vyshnepolsky M   +6 more
europepmc   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

The importance of local context in the planning of environmental projects: examples from two biogas cases

open access: yes, 2005
The planning of facilities to improve the environment is often carried through in the form of locally based construction projects. These projects can be complex, involving a variety of issues and a number of different actors from both the public and ...
Khan, Jamil,, Lund University.
core  

Macrophage-derived extracellular vesicles regulate follicular activation and improve ovarian function in old mice by modulating local environment. [PDF]

open access: yesClin Transl Med, 2022
Xiao Y   +12 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling   +16 more
wiley   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao   +6 more
wiley   +1 more source

Proximate Drivers of Population-Level Lizard Gut Microbial Diversity: Impacts of Diet, Insularity, and Local Environment. [PDF]

open access: yesMicroorganisms, 2022
Lemieux-Labonté V   +8 more
europepmc   +1 more source

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