Results 61 to 70 of about 1,201,861 (268)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Local Affine Optical Flow Computation [PDF]
, 2014 We develop an algorithm for the computation of a locally affine optical flow field as an extension of the Lucas-Kanade LK method. The classical LK method solves a system of linear equations assuming that the flow field is locally constant. Our method solves a collection of systems of linear equations assuming that the flow field is locally affine ...
Hayato Itoh +5 more
openaire +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Locally compact measure preserving flows
Advances in Mathematics, 1975 Ergodic theory originally arose from study of the time evolution of a mechanical system. If T, denotes the transformation of the phase space of a system which takes a state of the system to its state t time units later, then on physical grounds (T,: t E @ obeys the group property that T,,, = T,T, , i.e., forms a flow with parameter group R.
openaire +2 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Local Scour of Spur Dike in Unsteady Flow
工程科学与技术, 2014 :Water damage phenomenon of spur dike is widespread and influenced by many factors,and the current research results on it is under the condition of constant flow,which can’t be good enough to solve practical problems.Through flume model experiment,under
喻涛, 王平义, 陈里, 李红
doaj
Insect-Inspired Micropump: Flow in a Tube with Local Contractions
Micromachines, 2015 A biologically-inspired micropumping model in a three-dimensional tube subjected to localized wall constrictions is given in this article. The present study extends our previous pumping model where a 3D channel with a square cross-section is considered ...
Yasser Aboelkassem
doaj +1 more source