Results 51 to 60 of about 1,744 (255)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

On fractional deviation operators

Le Matematiche, 1997
The so called fractional deviation operators are introduced. This class of integral transforms appears naturally from the study of iteration of fractional integrals of Riemann-Liouville type. Since B.
Carlos C. Peña
doaj  

Double Local Fractional Yang–Laplace Transform for Local Fractional PDEs on Fractal Domains

Fractal and Fractional
This study introduces a novel analytical technique known as the double local fractional Yang–Laplace transform method (LFLζ2) and rigorously investigates its foundational properties, including linearity, differentiation, and convolution.
Djelloul Ziane, Mountassir Hamdi Cherif, Carlo Cattani, Abdelhamid Mohammed Djaouti   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Hermite–Hadamard- and Pachpatte-type integral inequalities for generalized subadditive functions in the fractal sense

Miskolc Mathematical Notes
In this paper, we establish the generalized Hermite–Hadamard- and Pachpatte-type integral inequalities for local fractional integrals via the generalized subadditive functions.
Tingsong Du, Lei Xu
doaj   +1 more source

The nonlocal problem for fractal diffusion equation

Міжнародний науково-технічний журнал "Проблеми керування та інформатики", 2023
Over the past few decades, the theory of pseudodifferential operators (PDO) and equations with such operators (PDE) has been intensively developed. The authors of a new direction in the theory of PDE, which they called parabolic PDE with non-smooth ...
Ярослав Михайлович Дрінь, Ірина Ігорівна Дрінь, Світлана Сергіївна Дрінь   +2 more
doaj   +1 more source

Local discontinuous Galerkin method for the integral fractional Laplacian

CoRR
We develop and analyze a local discontinuous Galerkin (LDG) method for solving integral fractional Laplacian problems on bounded Lipschitz domains. The method is based on a three-field mixed formulation involving the primal variable, its gradient, and the corresponding Riesz potential, yielding a flux-based structure well suited for LDG discretizations
Rubing Han, Shuonan Wu, Hao Zhou
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source