Results 61 to 70 of about 1,744 (255)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Some Generalized Inequalities Involving Local Fractional Integrals and their Applications for Random Variables and Numerical Integration [PDF]

Journal of Applied Mathematics, Statistics and Informatics, 2016
AbstractWe establish generalized pre-Grüss inequality for local fractional integrals. Then, we obtain some inequalities involving generalized expectation,p−moment, variance and cumulative distribution function of random variable whose probability density function is bounded.
Erden, Samet, Sarikaya, M. Z., Celik, N., Erden, Samet   +3 more
openaire   +3 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

About a Problem for Loaded Parabolic-Hyperbolic Type Equation with Fractional Derivatives

International Journal of Differential Equations, 2016
An existence and uniqueness of solution of local boundary value problem with discontinuous matching condition for the loaded parabolic-hyperbolic equation involving the Caputo fractional derivative and Riemann-Liouville integrals have been investigated ...
Kishin B. Sadarangani, Obidjon Kh. Abdullaev   +1 more
doaj   +1 more source

Rough Fractional Integral Operators on Local Morrey Spaces

Journal of Physics: Conference Series, 2019
We prove the boundedness of rough fractional integral operator on local Morrey spaces for radial functions. We consider three ways of estimation of the operator to obtain our result.
Daniel Salim, Wono Setya Budhi, Yudi Soeharyadi   +2 more
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Parameterized Fractal–Fractional Analysis of Ostrowski- and Simpson-Type Inequalities with Applications

Fractal and Fractional
In this paper, we first introduce a parametric identity for generalized differentiable functions using a generalized fractal–fractional integral operators.
Saad Ihsan Butt, Muhammad Mehtab, Youngsoo Seol   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Generalized Pompeiu type inequalities for local fractional integrals and its applications

Applied Mathematics and Computation, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Erden, Samet, Sarikaya, Mehmet Zeki, Erden, Samet   +2 more
openaire   +1 more source