Results 21 to 30 of about 9,573,379 (271)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Business Intelligence in a Local Government Unit [PDF]
InSITE Conference, 2015 Business Intelligence is important tools to improve business processes. More and more companies, government units use BI. But there are not still so many solutions which can be applied in local government units. From this reason the paper has been devoted to the supporting managerial decision-making processes in the Polkowice commune, Poland using BI
Malgorzata Ewa Nycz, Zdzislaw Polkowski
openaire +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Local Government Excellence Programme prospectus – overview [PDF]
, 2016 The 2015 New Zealand Local Government Survey found residents and businesses had a low awareness of the full services councils provide and the value they bring.
Local Government New Zealand
core
The Structure of Income of Lubuskie Local Government Units [PDF]
Ekonomiczne Problemy Usług, 2018 This study is of descriptive and explanatory character. It refers to the presentation of income of Lubuskie local government units in 2015–2016 in the area of financial independence and depiction of income items in the budget structure of municipalities.
openaire +2 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Leadership in local government units
Zbornik Matice srpske za drustvene nauke, 2016 Local governments represent the specific legal entities whose mission is to create a better living conditions for its citizens. Market conditions require the introduction of a high level of efficiency in business, which is reflected in the management of capital and human resources.
openaire +2 more sources