Results 31 to 40 of about 9,573,379 (271)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Hypertriglyceridemia is associated with decline of estimated glomerular filtration rate and risk of end-stage kidney disease in a real-word Italian cohort: Evidence from the TG-RENAL Study [PDF]
, 2023 Background: This analysis investigated the role of hypertriglyceridemia on renal function decline and develop-ment of end-stage kidney disease (ESKD) in a real-world clinical setting.
Perrone V. +8 more
core +1 more source
Local government climate action key performance indicators – in an Irish context [PDF]
, 2022 The Irish local government sector is a key player with respect to the State meeting its climate change commitment of net zero greenhouse gas emissions by no later than the end of 2050. Its broad operational remit in providing over 1,000 services, many of
Clarke, Darren
core +2 more sources
Developing a Philippine Local Government Bond Market [PDF]
The 1991 Local Government has initiated comprehensive changes in Philippine public administration such as decentralization and greater local autonomy. However, the macroeconomic picture has been characterized by volatile inflation, foreign exchange and ...
Laya, Jaime C.
core +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Fiscal Stability of the Local Government Units in the Republic of Srpska
Economic Themes, 2021 Abstract Fiscal stability of the local self-government units is the condition for stable public finances of the Republic of Srpska (hereinafter: RS) as a whole. Stable public finances of local self-government units have a positive impact on the economic growth of the RS. Therefore, it is necessary to pay a significant attention to the
Gojković, Biljana +2 more
openaire +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Public utility fees as own revenues of local self-government units in the territory of Autonomous Province of Vojvodina [PDF]
Zbornik Radova Pravnog Fakulteta u NišuThe process of fiscal decentralization, as a typical feature of contemporary societies, implies the transfer of public functions and public revenues from higher to lower levels of authorities in order to ensure the financing of the transferred functions.
Cvetković-Ivetić Cvjetana +1 more
doaj +1 more source