Results 51 to 60 of about 136,937 (218)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Resource Management in Local Governments: A Bane or a Boon to Development at the Local Level in Ghana [PDF]
International Journal of Management, Accounting and EconomicsThe decentralised local government system makes funds available to local governments to develop the communities and improve living conditions of the people.
Anthony Aikins +2 more
doaj +1 more source
REVENUE-SHARING FUND AND PERFORMANCE OF LOCAL GOVERNMENTS [PDF]
Russian Journal of Agricultural and Socio-Economic Sciences, 2022 This study examines the relationship between revenue sharing funds and local government performance in Indonesia. The sample included 481 local governments in 2016. The results of this study provide the following empirical evidence.
Ardila L.N., Adiati A.K., Sutopo B.
doaj
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Governance in urban development crisis situations
Anali Hrvatskog Politološkog Društva, 2008 Urban shrinking processes are increasingly recognized as a phenomenon for research in urban politics, encompassing entire cities or parts of it as well as metropolitan areas that are experiencing a fundamental decline in both their economic and social ...
Jörg Rober
doaj
Economics and EnvironmentThis paper investigates the relationship between the financial situation of local governments (LGs) and the awarding of circular public procurements (CPP) within the circular economy.
Małgorzata Godlewska +1 more
doaj +1 more source
COMPETENCE OF LOCAL SELF-GOVERNMENTS: DEBATABLE ISSUES
Правоприменение, 2018 Subject. The article is devoted to the discussion issues of competence of local self-government.The purpose of this paper is to show that the federal government passes such laws in order to build a single “power vertical” from a rural settlement to a ...
Y. Blagov
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source