Results 101 to 110 of about 8,430,021 (340)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A local group differences test for subject-level multivariate density neuroimaging outcomes. [PDF]

Biostatistics, 2021
Dworkin JD, Linn KA, Solomon AJ, Satterthwaite TD, Raznahan A, Bakshi R, Shinohara RT.   +6 more
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Bacterial Infections and Their Cell Wall Ligands Differentially Modulate Doxorubicin Sensitivity in Triple-Negative Breast Cancer Cells

Microorganisms
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options and poor clinical outcomes. Emerging evidence suggests that the tumor-associated microbiome may influence disease progression and therapy response ...
Sima Kianpour Rad, Runhao Li, Kenny K. L. Yeo, Fangmeinuo Wu, Yoko Tomita, Timothy J. Price, Wendy V. Ingman, Amanda R. Townsend, Eric Smith   +8 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Glioblastoma Recurrence Correlates With Increased APE1 and Polarization Toward an Immuno-Suppressive Microenvironment

Frontiers in Oncology, 2018
While treatment with surgery, radiotherapy and/or chemotherapy may prolong life for patients with glioblastoma, recurrence is inevitable. What is still being discovered is how much these treatments and recurrence of disease affect the molecular profiles ...
Amanda L. Hudson, Amanda L. Hudson, Amanda L. Hudson, Nicole R. Parker, Nicole R. Parker, Nicole R. Parker, Peter Khong, Peter Khong, Peter Khong, Jonathon F. Parkinson, Jonathon F. Parkinson, Jonathon F. Parkinson, Trisha Dwight, Trisha Dwight, Trisha Dwight, Rowan J. Ikin, Rowan J. Ikin, Rowan J. Ikin, Ying Zhu, Ying Zhu, Ying Zhu, Jason Chen, Helen R. Wheeler, Helen R. Wheeler, Helen R. Wheeler, Viive M. Howell, Viive M. Howell, Viive M. Howell   +27 more
doaj   +1 more source

Local cross sections in locally compact groups [PDF]

Proceedings of the American Mathematical Society, 1953
Introduction. Let p be the natural projection of the topological group G, with subgroup H, onto the coset space G/H. The subgroup H is said to have a local cross section if there exists an open set U in G/H, and a continuous function f defined on U with values in G such that pf(x) x for x in U.
openaire   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

HST Proper Motions of Andromeda V and Andromeda VI

The Astrophysical Journal
We measure the absolute proper motions of Andromeda V (And V) and Andromeda VI/Pegasus (And VI) dwarf galaxies, satellites of M31 located near its galactic plane.
Dana I. Casetti-Dinescu, Marcel S. Pawlowski, Terrence M. Girard, Kosuke Jamie Kanehisa, Max Martone, Alexander Petroski   +5 more
doaj   +1 more source

LOCAL SYSTEMS OF LOCALLY SUPERSOLUBLE FINITARY GROUPS [PDF]

Glasgow Mathematical Journal, 2003
Let \(D\) be a division algebra that is locally finite dimensional over some perfect field and let \(V\) be a vector space over \(D\). The author considers subgroups of the finitary general linear group \(\text{FGL}(V)\) of \(V\) over \(D\). He seeks supersoluble analogues of results of the reviewer concerning nilpotence.
openaire   +2 more sources