Results 91 to 100 of about 2,860,329 (252)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Local Government Improvement in England: Policies, Progress and Prospects

open access: yesCommonwealth Journal of Local Governance, 2011
Whilst many countries have been devolving power to the sub-national level England has moved in the opposite direction. For the last decade English local government has been subjected to tight top down performance monitoring and financial controls.
Steve Martin
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Local Area Improvement of GSM Network Coverage

open access: yesEngineering Proceedings
This article describes the design of a local GSM signal amplifying system and presents the results of appliance performance measurements, simulations and analyses.
Miroslav Tomov   +3 more
doaj   +1 more source

DOES THE LOCAL ECONOMIC GOVERNANCE IN INDONESIAPERFORM AN IMPROVEMENT?

open access: yesBuletin Ekonomi Moneter dan Perbankan, 2012
Governance has gone through radical changes over the last twenty five years. Seemingly, it became one of the important strategies, processes, methods and mechanisms in governing countries to achieve economic development goals. The objective of this paper
Haryo Kuncoro
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Community Care of North Carolina: Putting Health Reform Ideas Into Practice in Medicaid [PDF]

open access: yes, 2009
Summarizes assessments of how an enhanced medical home model of care that involves local nonprofit community networks and emphasizes care coordination, disease and care management, and quality improvement has affected cost savings and quality of ...
Samantha Artiga
core  

Data-Driven Power Control for State Estimation: A Bayesian Inference Approach

open access: yes, 2015
We consider sensor transmission power control for state estimation, using a Bayesian inference approach. A sensor node sends its local state estimate to a remote estimator over an unreliable wireless communication channel with random data packet drops ...
Lau, Vincent   +4 more
core   +2 more sources

Metabolic Engineering for Enhanced Medium Chain Omega Hydroxy Fatty Acid Production in Escherichia coli

open access: yesFrontiers in Microbiology, 2018
Medium chain hydroxy fatty acids (HFAs) at ω-1, 2, or 3 positions (ω-1/2/3) are rare in nature but are attractive due to their potential applications in industry. They can be metabolically engineered in Escherichia coli, however, the current yield is low.
Kang Xiao   +16 more
doaj   +1 more source

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