Results 41 to 50 of about 567 (213)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A low-cost spatial tool for transforming feature positions of CAD-based topographic mapping

Geodesy and Cartography, 2019
In fact, Computer Aided Design (CAD) offers powerful design tools to produce digital large scale topographic mapping that is considered the backbone for construction projects, urban planning and landscape architecture.
Maan Habib, A’kif Alfugara, Biswajeet Pradhan   +2 more
doaj   +1 more source

Mapping Australia’s precipitation: harnessing the synergies of multi-satellite remote sensing and gauge network data

GIScience & Remote Sensing, 2022
Coverage, resolution, and accuracy in the spatial and temporal estimates of remotely sensed precipitation from space satellites, along with the number of instruments deployed to deliver these observations, are increasing. Of key interest in this study is
Benjamin Hines, Guoqi Qian, Antoinette Tordesillas   +2 more
doaj   +1 more source

On derivative estimation and the solution of least squares problems

, 2008
Surface interpolation finds application in many aspects of science and technology. Two specific areas of interest are surface reconstruction techniques for plant architecture and approximating cell face fluxes in the finite volume discretisation strategy
Belward, John A., Turner, I. W., Turner, Ian, Belward, J. A., Ilić, Miloš, Ilic, M., Turner, Ian W., Belward, John   +7 more
core   +1 more source

A derivative-free algorithm for least-squares minimization [PDF]

, 2010
We develop a framework for a class of derivative-free algorithms for the least-squares minimization problem. These algorithms are based on polynomial interpolation models and are designed to take advantages of the problem structure.
Zhang, Hongchao, Andrew R. Conn, Katya Scheinberg, Conn, Andrew R., Hongchao Zhang, Scheinberg, Katya   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Development of a new meshless — point weighted least-squares (PWLS) method for computational mechanics

, 2004
A truly meshless approach, point weighted least-squares (PWLS) method, is developed in this paper. In the present PWLS method, two sets of distributed points are adopted, i.e. fields node and collocation point.
Li, Hua, Wang, Q. X., Lam, K. Y.
core   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source