Results 131 to 140 of about 181,898 (305)

A CASE OF MALIGNANT RENAL NEOPLASM WITH RHABDOID FEATURES IN AN ADULT

, 2001
We report a case of malignant neoplasm with rhabdoid features of the kidney in a 68 year old man. To our knowledge malignant rhabdoid tumor of the kidney (MRTK) has been limited to the pediatric age group.
Ichijima, Kunio, Ozono, Seiichiro, Yoshii, Masato, Mibu, Hisakazu, Kumamoto, Hiromi, Hosokawa, Yukinari, Tsujimoto, Sigehiro, Kagebayashi, Yoriaki, Kitauchi, Takanori, Hirao, Yoshihiko   +9 more
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Clinical Outcome of Surgically Resected Pancreatic Intraductal Papillary Mucinous Neoplasm According to the Marginal Status: A Single Center Experience

, 2010
Background: Surgical resection is the treatment of choice of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. However, the benefit of clearing resection margin is still controversial.
Jihun Kim, Song Cheol Kim, Yu, Eunsil, Kim, Song Cheol, Kim, Sun A., Kim, Jihun, Sun A Kim, Eunsil Yu   +7 more
core   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Recurrent solid pseudopapillary neoplasm of the pancreas with hepatic and lymphatic metastasis in a teenager: A case report

Introduction: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm with low malignant potential, predominantly affecting young women. Despite its generally favorable prognosis following complete resection, recurrence or metastasis may ...
Ngoc Nguyen Bich, Trang Dang Thi Huyen, Phuong Tran Ha, Hoa Nguyen Viet, Tuan Vu Hong, Phuc Chu Minh   +5 more
core   +1 more source

Epithelioid Hemangioma of Bone: A Rare Vascular Neoplasm. A Case Report and Literature Review

, 2022
Epithelioid hemangioma (EH) of bone is a rare benign, albeit locally aggressive vascular neoplasm. It is usually solitary and involves the metaphysis or diaphysis of long tubular bones, especially in the lower extremities.
Sioutis, S., Papagelopoulos, P., Melissaridou, D., Lakiotaki, E., Vottis, C., Gavriil, P., Savvidou, O., Korkolopoulou, P.   +7 more
core  

Locally aggressive recurrent sebaceous carcinoma of the scalp with post-auricular ‘kissing ulcer’: an infrequent skin appendageal neoplasm at unusual location

International Journal of Research in Medical Sciences
Sebaceous carcinoma is an infrequent malignancy that arises from skin appendageal system. It is usually common in elderly age with slightly female preponderance. Asian population have higher incidence of this malignancy. Most commonly it occurs in orbital region (75%) and rarely this tumour presents in extraocular regions like scalp, face, genitalia ...
Mahesh Jangra, Parampreet Singh Saini, Harshavardhan Shetty, Satyaswarup Tripathy   +3 more
openaire   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source