Results 201 to 210 of about 185,531 (315)

Effect of Surgical Margins on Local Recurrence Patterns of Myxofibrosarcomas: A Retrospective Cohort Study From the Stockholm Sarcoma Centre. [PDF]

J Surg Oncol
Hoang MN, Doumanidis P, Nyqvist E, Löfgren J, Hesla AC, Tsagkozis P.   +5 more
europepmc   +1 more source

Hyaluronic Acid Hydrogel Implants for Sustained Release of Oxaliplatin and Resiquimod to Prevent Hepatocellular Carcinoma Recurrence Post‐Radiofrequency Ablation

Advanced Science, EarlyView.
Preparation of a biopolymer‐based immune implant (BI) for the sustained release of R848 and oxaliplatin (OXA), enabling immune activation and preventing recurrence after radiofrequency ablation (RFA) treatment in hepatocellular carcinoma (HCC). Abstract Hepatocellular carcinoma (HCC) remains a global challenge due to limited therapies and high ...
Yuezhan Shan, Hongyu Chu, Sheyu Ye, Guofeng Ji, Jiayi Zhao, Xinghui Si, Yumin Zhong, Youmao Tao, Jingwei Shi, Xuedong Fang   +9 more
wiley   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Xiao Yang, Xiaoxuan Wu, Bing Wei, Jianmin Ying, Jian Yan, Wenbin Li   +11 more
wiley   +1 more source

Adult fibrosarcoma: From clinical challenges to cutting-edge innovations. [PDF]

Oncoscience
Sultana R, Sailaja S.
europepmc   +1 more source

Near‐Infrared‐Responsive Digital PCR‐Assisted Renal Cancer Exosomal miRNAs Insights and Regulation of Macrophage Polarization

Advanced Science, EarlyView.
A near‐infrared‐responsive digital Polymerase Chain Reaction technique with triple‐color coding profiles renal cancer exosomal microRNA biomarkers and their impact on macrophage polarization. Engineered miR‐34‐loaded exosomes via electroporation saturate molecular sponges, downregulating STAT3 in recipient macrophages to prolong M2 polarization. Stable
Lexiang Zhang, Rokshana Parvin, Siyue Lin, Peiyu Chen, Gangling Wang, Dingmeng Hu, Ke Lin, Yun Cheng, Fangfu Ye, Bing Han, Gen Yang, Dexuan Wang   +11 more
wiley   +1 more source

Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysis. [PDF]

Rev Bras Ginecol Obstet
Santos GML, Magalhães AO, Teichmann PDV, Wender MCO.   +3 more
europepmc   +1 more source

Endoscopic submucosal dissection for colorectal neoplasms: Risk factors for local recurrence and long-term surveillance

Endoscopic submucosal dissection for colorectal neoplasms: Risk factors for local recurrence and long-term surveillance
2024年度
openaire  

Intravenous iRGD‐Guided, RBC‐Membrane Camouflaged Lactococcus Lactis Remodels Cold NSCLC and Enhances PD‐1 Blockade

Advanced Science, EarlyView.
This study presents an engineered probiotic platform, iRGD‐mRBC@FOLactis, combining red blood cell membrane cloaking and tumor‐penetrating peptide iRGD for enhanced PD‐1 blockade. The platform improves tumor targeting, immune cell activation and therapeutic efficacy in lung cancer, demonstrating significant promise in overcoming PD‐1/PD‐L1 therapy ...
Chen Chen, Junmeng Zhu, Xiao Liu, Jie Shao, Aoxing Chen, Yi Mei, Xinyin Zhang, Qinyi Chen, Lin Li, Baorui Liu   +9 more
wiley   +1 more source

Local recurrence of phyllodes tumors after surgery with wide compared to narrow margins: study protocol for a systematic review and meta-analysis. [PDF]

Syst Rev
Sars C, Frisell J, Dickman PW, Sackey H, Lindqvist EK.   +4 more
europepmc   +1 more source

Hypoxia‐Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis

Advanced Science, EarlyView.
Hypoxia triggers lactylation of PRMT1 at K134/K145, enhancing its methyltransferase activity to asymmetrically dimethylate vimentin R64. This post‐translational cascade promotes vimentin filament assembly, cytoskeletal remodeling, and tumor metastasis, with PRMT1 inhibition (MS023) reducing metastatic colonization.
Jia Zhou, Shuying Qiu, Xia Yang, Yan Wu, Xinxia Yao, Hangqi Hu, Jingfeng Luo, Chandra Sugiarto Wijaya, Lingfeng Ma, Xiaojun Long, Lingna Xu, Jinquan Liu, Chaoqun Wang, Yibin Pan, Xiaona Chen, Hongchuan Jin, Xian Wang   +16 more
wiley   +1 more source