Results 231 to 240 of about 181,898 (305)

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Giant Cell Tumor of the Sacrum: A Narrative Review of Management Challenges and Modalities. [PDF]

Healthcare (Basel)
Alaseem A, Aldosari ZA, Alduraibi AA, Alzahrani RK, AlNahari AS, AlAqeel M, Alshaygy I.   +6 more
europepmc   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

A Rare Epithelioid Hemangioendothelioma of the Tongue: A Case Report and Review of Published Cases. [PDF]

Case Rep Dent
Gioco G, Patini R, Russo E, Rindi G, Lajolo C, Rupe C.   +5 more
europepmc   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Long-Term Disease-Free Survival After Systemic-First Sequential Multimodal Therapy for Advanced and Recurrent Large-Cell Neuroendocrine Carcinoma of the Uterine Cervix: A Case Report. [PDF]

J Obstet Gynaecol Res
Wakana K, Akita M, Tsubata F, Kori Y, Odai T, Miyasaka N.   +5 more
europepmc   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Rapidly Progressive Giant Malignant Phyllodes Tumor of the Breast: A Surgical Challenge. [PDF]

Cureus
Xanthopoulou G, Theodorolea K, Barkolias C, Spyrou I, Tasis NP.   +4 more
europepmc   +1 more source

No difference in prognosis between atypical intradermal smooth muscle neoplasms and dermal leiomyosarcoma: Local recurrence, metastasis, and overall survival in a nationwide cohort of 423 patients

Journal of the American Academy of Dermatology
Abebe, Kiya, Ørholt, Mathias, Bak, Erik E. F., Larsen, Andreas, Wagenblast, Anne Lene, Schmidt, Grethe, Jensen, David Hebbelstrup, Petersen, Michael M., Loya, Anand C., Daugaard, Søren, Herly, Mikkel, Hornick, Jason L., Mentzel, Thomas, Vester-Glowinski, Peter   +13 more
openaire   +3 more sources