Results 141 to 150 of about 225,245 (281)

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Unpaired Learning‐Enabled Nanotube Identification from AFM Images

Advanced Science, EarlyView.
Identifying nanotubes on rough substrates is notoriously challenging for conventional image analysis. This work presents an unpaired deep learning approach that automatically extracts nanotube networks from atomic force microscopy images, even on complex polymeric surfaces used in roll‐to‐roll printing.
Soyoung Na, Soobin Park, Younsu Jung, Jinhwa Park, Jimin Hong, Jihyun Lee, Albert Kim, Bongjun Kim, Gyoujin Cho, Eunju Cha, Seung Hyun Song   +10 more
wiley   +1 more source

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

A Novel Peak-Shape Aware Approach for Mass Alignment in Mass Spectrometry. [PDF]

Rapid Commun Mass Spectrom
Vanhemel T, Nijs M, Birmpili A, Hendriks TFE, Cuypers E, De Moor B.   +5 more
europepmc   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

A new hybrid model for improving outlier detection using combined autoencoder and variational autoencoder. [PDF]

Sci Rep
Daoud AM, Elkomy OM, Khedr WI, Hosny KM.
europepmc   +1 more source

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Development of Hourly Resolution Air Temperature Across Titicaca Lake on Auxiliary ERA5 Variables and Machine Learning-Based Gap-Filling. [PDF]

Sensors (Basel)
Sirpa-Poma JW, Calle J, Uscamayta-Ferrano E, Molina-Carpio J, Satgé F, Cuentas Toledo O, Duran R, Pacheco Mollinedo P, Hussain R, Pillco-Zolá R.   +9 more
europepmc   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

GL-VSLAM: A General Lightweight Visual SLAM Approach for RGB-D and Stereo Cameras. [PDF]

Sensors (Basel)
Li X, Li T, Zhang Y, Li Z, Ban L, Ning Y.   +5 more
europepmc   +1 more source