Results 141 to 150 of about 696,171 (284)

Safe-RTSKF: A Safety-Constrained Recursive Two-Stage Kalman Filter for Robust Sensor State Estimation in Strongly Nonlinear Systems. [PDF]

Sensors (Basel)
Lin Y, Liu Z, Wen C, Ye K, Jeong YK, Zhou S, Zheng X.   +6 more
europepmc   +1 more source

On the Relationship between $\Lambda$-poisedness in Derivative-Free Optimization and Outliers in Local Outlier Factor

Comment: 11 ...
Zhang, Qi, Xie, Pengcheng
openaire   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Enhancing Data Quality in Clinical Trials: Cross-Company Validation of the Open-Source Clinical Trial Anomaly Spotter (CTAS). [PDF]

Ther Innov Regul Sci
Tiikkainen P, Collin F, Koneswarakantha B.   +2 more
europepmc   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

The population structure in the Baltic herring reflects natural selection and local adaptation. [PDF]

Proc Natl Acad Sci U S A
Goodall J, Pettersson ME, Andersson A, Dahlin I, Ryman N, Ståhl G, Wennerström L, Andersson L, Laikre L.   +8 more
europepmc   +1 more source

Brain‐Computer Interface Training Fosters Perceptual Skills to Detect Errors

Advanced Science, EarlyView.
Accurate perception of visuomotor errors underpins motor precision and learning, yet conventional behavioral training fails to improve sensitivity to subtle errors. Real‐time EEG‐based brain‐computer interface feedback targeting the error positivity component enhances perceptual learning of small errors.
Deland H. Liu, Fumiaki Iwane, Minsu Zhang, Leonardo G. Cohen, José del R. Millán   +4 more
wiley   +1 more source

Pleiotropy and Facilitation of Local Adaptation in the Silverleaf Sunflower Helianthus argophyllus. [PDF]

Genome Biol Evol
Okinedo UE, Moyers BT.
europepmc   +1 more source

Research on battery inconsistency evaluation based on improved local outlier factor and fuzzy matrix

Journal of Energy Storage
Jichao Hong, Kerui Li, Fengwei Liang, Haixu Yang, Yankai Hou, Fei Ma, Facheng Wang, Xinyang Zhang, Huaqin Zhang, Chi Zhang   +9 more
semanticscholar   +1 more source

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, EarlyView.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source