Results 191 to 200 of about 48,666 (293)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

The Signal in the Extreme: A Systematic Outlier Framework Identifies Discrete Immunometabolic Subtypes in Human and Cellular Models. [PDF]

Med Sci (Basel)
Garcia-Coste JJ, Aguayo-Cerón KA, Espinosa-Raya J, García-Rivero AA, López-Leyva C, Gutiérrez-Rojas RA, Vargas-De-León C, Romero-Nava R.   +7 more
europepmc   +1 more source

Deteksi Anomali pada Rasio Jam Belajar dan Aktivitas Sosial terhadapPerforma Akademis Mahasiswa menggunakan Metode Local Outlier Factor (LOF)

Abdul Kadir Jailani, Angdy Erna
openalex   +2 more sources

A High‐Throughput Live Imaging Platform to Investigate Circuit‐Dependent Regulation of Circadian Rhythms in Brain Tissue

Advanced Science, EarlyView.
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari, Natalie Ness, Julieta Acosta, Marco Brancaccio   +3 more
wiley   +1 more source

Signatures of repeated genomic selection associated with human-modified landscapes in genetically independent populations of Rhinella horribilis. [PDF]

Heredity (Edinb)
Soria-Ortiz GJ, Vázquez-Domínguez E.
europepmc   +1 more source

Data‐Driven Modeling of Composition–Processing–Microstructure Relations for Recycled Aluminum Cast Alloys

Advanced Science, EarlyView.
Interpretable machine learning reveals how composition and processing govern the formation and microstructural burden of Fe‐rich intermetallic compounds in recycled Al–Si–Fe–Mn alloys. By separating morphology selection from morphology‐conditioned burden partitioning, this framework shows that identical Fe contents can yield different intermetallic ...
Jaemin Wang, Waleed Mohammed, Dierk Raabe   +2 more
wiley   +1 more source

Studi Komparasi Local Outlier Factor (LOF) dan Isolation Forest (IF) pada Analisis Anomali Kinerja Dosen

Mutmainah Mutmainah, Wiyli Yustanti
openalex   +2 more sources

Data-Driven Event Detection of Power Systems Based on Unequal-Interval Reduction of PMU Data and Local Outlier Factor

, 2019
Shengyuan Liu, Yuxuan Zhao, Zhenzhi Lin, Yilu Liu, Yi Ding, Li Yang, Shimin Yi   +6 more
openalex   +2 more sources

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, EarlyView.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

The Chalk Streams of Southern England and Northern France Harbour Substantial Unique Components of the Overall Genetic Diversity of Atlantic Salmon (<i>Salmo salar</i> L.). [PDF]

Evol Appl
King RA, Evanno G, Stevens JR.
europepmc   +1 more source