The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi +11 more
wiley +1 more source
Expanded Group Additivity Framework for Thermochemical Prediction of Fluorocarbons and PFAS from Large-Scale DFT Data. [PDF]
Eccles S, Pellizzeri S.
europepmc +1 more source
A dynamic Ag+─S coordinated hydrogel with a sulfur–oxygen competitive coordination allosteric switch enables reversible tuning between soft–adhesive and stiff–robust states. Integrated with a lightweight 1DCNN classifier, the smart glove system achieves 99.70% laboratory and 93.35% real‐wear material recognition accuracy, offering a paradigm for self ...
Shixia Lan +4 more
wiley +1 more source
Potential Association Between Basal Metabolic Rate and Presbyopia: A Two-Sample Mendelian Randomisation Study. [PDF]
Lee Y, Seo JH.
europepmc +1 more source
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling +18 more
wiley +1 more source
FLIMExplorer: interactive GUI for object-based visualization and analysis of fluorescence lifetime images. [PDF]
Ter Hofstede B +5 more
europepmc +1 more source
Unraveling causal links between chronic rhinosinusitis and peripheral artery diseases: insights from genetic correlations through genome-wide association studies. [PDF]
Wei B, He J, Gan W, Wang B, Liu F.
europepmc +1 more source
Adaptation across an extreme elevational gradient in Andean leaf-eared mice, the world's highest-dwelling mammal. [PDF]
Liphardt S +21 more
europepmc +1 more source
Ancient inversion polymorphisms are locally adaptive in a widespread butterfly species. [PDF]
Seixas FA +12 more
europepmc +1 more source
Serum protein biomarkers for polymyalgia rheumatica: a case-control study. [PDF]
Furukawa H +6 more
europepmc +1 more source

