Results 221 to 230 of about 225,245 (281)

Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

Advanced Science, EarlyView.
Bioorthogonal SDPTAC harnesses US‐responsive Ce6‐TCO and Tz ligands via IEDDA click chemistry to assemble degraders in situ, generating ROS that selectively eliminate nuclear, cytosolic, and membrane proteins, thereby suppressing deep‐seated tumors in vivo.
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng   +8 more
wiley   +1 more source

Fault detection for Li-ion batteries of electric vehicles with feature-augmented attentional autoencoder. [PDF]

Sci Rep
Fan Y, Huang Z, Li H, Yuan W, Yan L, Liu Y, Chen Z.   +6 more
europepmc   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Feature-Based Normality Models for Anomaly Detection. [PDF]

Sensors (Basel)
Teh HY, Wang KI, Kempa-Liehr AW.
europepmc   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Research on an intelligent drilling parameter optimization method using sliding window segmentation based on the hydraulic-mechanical specific energy model. [PDF]

PLoS One
Li W, Liu Y, Li X, Deng B, Zhao H, Zhu L, Zain U.   +6 more
europepmc   +1 more source

EODA: A three-stage efficient outlier detection approach using Boruta-RF feature selection and enhanced KNN-based clustering algorithm. [PDF]

PLoS One
Kumar S, Varshney S, Jain U, Johri P, Almazyad AS, Mohamed AW, Hosseinzadeh M, Shokouhifar M.   +7 more
europepmc   +1 more source

Transcriptome differentiation in Cryptomeria japonica trees with different origins growing in the north and south of Japan. [PDF]

PLoS One
Ujino-Ihara T, Uchiyama K, Kanetani S, Suyama Y, Tsumura Y.   +4 more
europepmc   +1 more source