Results 61 to 70 of about 7,018,110 (249)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Stochastic Resonance Can Drive Adaptive Physiological Processes [PDF]

, 2009
Stochastic resonance (SR) is a concept from the physics and engineering communities that has applicability to both systems physiology and other living systems. In this paper, it will be argued that stochastic resonance plays a role in driving behavior in
Bradly J. Alicea
core  

Embroidered Coils for Magnetic Resonance Sensors [PDF]

, 2013
Magnetic resonance imaging is a widely used technique for medical and materials imaging. Even though the objects being imaged are often irregularly shaped, suitable coils permitting the measurement of the radio-frequency signal in these systems are ...
Newton, Michael, Dias, Tilak, Glen McHale, Tilak Dias, Michael Newton, Morris, Robert, McHale, Glen, Robert Morris, Morris, RH, Newton, MI, Dias, T, McHale, G   +11 more
core   +1 more source

Multi-Objective Optimization Design of Low-Frequency Band Gap for Local Resonance Acoustic Metamaterials Based on Genetic Algorithm

Machines
Driven by the urgent demand for low-frequency vibration and noise control in engineering scenarios such as automobiles, acoustic metamaterials (AMs), as a new class of functional materials, have demonstrated significant application potential.
Jianjiao Deng, Yunuo Qin, Xi Chen, Yanyong He, Yu Song, Xinpeng Zhang, Wenting Ma, Shoukui Li, Yudong Wu   +8 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Wind turbines as a metamaterial-like urban layer: an experimental investigation using a dense seismic array and complementary sensing technologies

Frontiers in Earth Science
The deflection and the control of the effects of the complex urban seismic wavefield on the built environment is a major challenge in earthquake engineering.
Marco Pilz, Philippe Roux, Shoaib Ayjaz Mohammed, Raphael F. Garcia, Rene Steinmann, Coralie Aubert, Felix Bernauer, Philippe Guéguen, Matthias Ohrnberger, Fabrice Cotton, Fabrice Cotton   +10 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Local and resonance vibrations in defect polymer solids

, 2020
The problem of local and resonance vibrational frequencies in a chain with a large number of degrees of freedom in a unit cell is studied. Repeat unit normal coordinates (RUNC's) are suggested as the most convenient representation for the numerical ...
Loghinov A.P.
core   +2 more sources

Numerical and Experimental Study of Low-Frequency Membrane Damper for Tube Vibration Suppression

Actuators
In modern days, low-frequency vibration is still challenging to suppress due to its high vibrational energy. A typical suppression method is to increase the object’s mass to reduce the amplitude of the vibration, but such a way is unsuitable in many ...
Boris I, Jaesun Lee
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source