Results 101 to 110 of about 618,863 (318)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Multiscale structural analysis of defective graphene in transmission electron microscopy images using persistent homology [PDF]

open access: yesAPL Materials
We developed a persistent-homology-based strategy that converts transmission electron microscopy images of defective graphene into quantitative, multiscale descriptors spanning local carbon-atom polygons and their global connectivity.
Ryuto Eguchi, Ayako Hashimoto
doaj   +1 more source

On monoid graded local rings

open access: yesJournal of Pure and Applied Algebra, 2012
24 pages with a few corrections and minor ...
openaire   +2 more sources

Homological Invariants of Local Rings [PDF]

open access: yesNagoya Mathematical Journal, 1963
In this paper R is a commutative noetherian local ring with unit element 1 and M is its maximal ideal. Let K be the residue field R/M and let {t1,t2,…, tn) be a minimal system of generators for M. By a complex R<T1. . ., Tp> we mean an R-algebra* obtained by the adjunction of the variables T1. . ., Tp of degree 1 which kill t1,…, tp.
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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