Results 71 to 80 of about 2,918,775 (291)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Existence, Stability and Sensitivity Analysis of Lyme Disease Using Caputo Fractional Dynamical Systems

Fractal and Fractional
In this article, mathematical modeling and stability analysis of Lyme disease and its transmission dynamics using Caputo fractional-order derivatives is presented.
Kashif Ullah, Nayyar Mehmood, Abdullah Eqal Al-Mazrooei, Jamshaid Ahmad   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Mathematical Model for the Control of Red Palm Weevil

Axioms
The red palm weevil (Rhynchophorus ferrugineus) is a highly destructive pest, causing severe damage to palm trees and significantly reducing their productivity.
Zuhur Alqahtani, Areej Almuneef, Moustafa El-Shahed   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Fractional Optimal Control Model and Bifurcation Analysis of Human Syncytial Respiratory Virus Transmission Dynamics

Fractal and Fractional
In this paper, the Caputo-based fractional derivative optimal control model is looked at to learn more about how the human respiratory syncytial virus (RSV) spreads.
Muath Awadalla, Jihan Alahmadi, Kumama Regassa Cheneke, Sania Qureshi   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Dynamical Analysis of Predator-Prey Model Leslie-Gower with Omnivore

Journal of Experimental Life Science, 2018
This article discussed a dynamical analysis on a model of predator-prey Leslie-Gower with omnivores which is modified by Lotka-Volterra model with omnivore.
Rina Exviani, Wuryansari Muharini Kusumawinahyu, Noor Hidayat   +2 more
doaj   +1 more source