Results 101 to 110 of about 3,086 (250)
THE SYSTEM OF LOCAL STATE BODIES AND ITS ROLE IN STATE ADMINISTRATION
This article describes the system of local state power, the structure of local executive power bodies, the duties and powers of local state power bodies.
Qo'chqarova Laylo Bahrom qizi +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Local Impact Assessment in the Czech Republic – the Theoretical Framework of Analysis
Littera Scripta, 2017 The text presents the theoretical framework of Local Impact Assessment presenting it as a new and effective tool of decision-making on the level of local administration.
Radek Soběhart, Aleš Rod, Jiřina Jílková
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Restructuring Measures, Upgrading and Rethinking of the Role and Functioning of the Government Under the Required Information Society. Case Study: Gorj [PDF]
The spirit of the Lisbon strategy (2000) defines a new opportunity to increase competitiveness at all levels, which is supported by the implementation of scientific knowledge, infrastructure and its implementation mechanisms to serve the new economy ...
Constantin Enea +2 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
, 2007 This paper presents a case study of accessibility evaluation which reports the main drawbacks concerning the accessibility of Web sites of French and Belgium local administrations.
Marco Winckler, Joseph Xiong
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Improving the effectiveness activity of the head bodies of executive authorities
Aspekti Publìčnogo Upravlìnnâ, 2015 The theoretical foundations of organizational and legal support of the head of executive power and grounded scientific conclusions and suggestions for its improvement. The classification of the activities of the head of executive power.
J. V. Voina
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