Results 51 to 60 of about 9,023 (169)

Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size [PDF]

, 2013
Follistatin-like 3 (FSTL3) is a glycoprotein that binds and inhibits the action of TGFβ ligands such as activin. The roles played by FSTL3 and activin signaling in organ development and homeostasis are not fully understood.
Abir Mukherjee, Alan L. Schneyer, Andrew A. Pitsillides, Archambeault, Baker, Bakker, Bartholin, Bastow, Besset, Brehm, Chan, Cohen, Cooke, Cooke, Cooke, Coultas, Coussens, Dierich, Do, Fujita, Gill, Hardwick, Itman, Jan Seebacher, Johnston, Judit Villen, Karla J. Oldknow, Kato, Kato, Kooy, Kumar, Lee, Matzuk, Mukherjee, Nef, Noriega, Parvinen, Peter J. O'Shaughnessy, Salisbury, Shang, Sharpe, Sidis, Slegtenhorst-Eegdeman, St-Pierre, Steeno, Steven P. Gygi, Tanimoto, Tapasree Goswami, Tolonen, Tsuchida, Turek, Wilhelm, Wreford, Xia, Yang   +54 more
core   +1 more source

Deep learning-based localization algorithms on fluorescence human brain 3D reconstruction: a comparative study using stereology as a reference [PDF]

Scientific Reports
Abstract3D reconstruction of human brain volumes at high resolution is now possible thanks to advancements in tissue clearing methods and fluorescence microscopy techniques. Analyzing the massive data produced with these approaches requires automatic methods able to perform fast and accurate cell counting and localization.
Checcucci, Curzio, Wicinski, Bridget, Mazzamuto, Giacomo, Scardigli, Marina, Ramazzotti, Josephine, Brady, Niamh, Pavone, Francesco S., Hof, Patrick R., Costantini, Irene, Frasconi, Paolo   +9 more
openaire   +4 more sources

Optimization of the Nonclinical Biological Evaluation of Medical Devices Using Toxicologic Pathology Best Practices

Advanced Healthcare Materials, Volume 15, Issue 3, 19 January 2026.
Nonclinical evaluation of biological responses to implanted medical devices and combination products in animals is required to predict possible outcomes and risks in patients. This paper describes globally accepted pathology “best practices” that 1) effectively address ISO standards and current regulatory guidance for medical device development and 2 ...
Kathleen A. Funk, JoAnn C. L. Schuh, Brad Bolon, Valerie S. Thomas, Jeffrey I. Everitt, Abraham Nyska, Jaime Paulin   +6 more
wiley   +1 more source

Metabolic changes during cardiac regeneration in the axolotl

Developmental Dynamics, Volume 255, Issue 1, Page 66-85, January 2026.
Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich, Sofie Amalie Andersson, Morten Busk, Kasper Hansen, Casper Bindzus Foldager, Johan Palmfeldt, Asger Andersen, Michael Pedersen, Mikkel Vendelbo, Kirstine Lykke Nielsen, Henrik Lauridsen   +10 more
wiley   +1 more source

Comparison between stereology methods for cell volume assessment : exemplified by estimation of neuronal nuclear volume in cirrhotic rats [PDF]

, 2007
The purpose of this paper is to compare the stereology methods to estimate cell volume. For particle volume estimates, a variety of local size estimators has been developed, beginning with assumption-based methods like planimetry.
Arias Pérez, Jorge Luis, Méndez López, Magdalena, Méndez López, Marta   +2 more
core  

The invariator Design: An update [PDF]

, 2015
The invariator is a method to generate a test line within an isotropically oriented plane through a fixed point, in such a way that the test line is effectively motion invariant in three dimensional space.
Cruz-Orive, Luis M., Gual-Arnau, Ximo
core   +4 more sources

Clinical and pathophysiological aspects of intrahepatic cholestasis of pregnancy [PDF]

, 2012
Objective: The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) involves impaired bile acid and estrogen/progesterone metabolism and excretion based on genetic and environmental factors. In this thesis we evaluated different pathophysiological
Wikström Shemer, Elisabeth A
core   +1 more source

On the Ambartzumian-Pleijel identity in hyperbolic geometry [PDF]

, 2014
We describe a hyperbolic version of the Ambartzumian-Pleijel identity. We use this identity to prove the hyperbolic Crofton formula and the hyperbolic isoperimetric inequality.
Binbin, Xu
core  

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, Volume 599, Issue 21, Page 3086-3102, November 2025.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Sampling for stereology in lungs

European Respiratory Review, 2006
The present article reviews the relevant stereological estimators for obtaining reliable quantitative structural data from the lungs. Stereological sampling achieves reliable, quantitative information either about the whole lung or complete lobes, whilst
J. R. Nyengaard, H. J. G. Gundersen
doaj