Results 71 to 80 of about 3,234,768 (265)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Local versus Global Time in Early Relativity Theory
EntropyIn his groundbreaking 1905 paper on special relativity, Einstein distinguished between local and global time in inertial systems, introducing his famous definition of distant simultaneity to give physical content to the notion of global time.
Dennis Dieks
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Local approximation of Markov chains in time and space
Journal of Biological Dynamics, 2019 In epidemic modelling, the emergence of a disease is characterized by the low numbers of infectious individuals. Environmental randomness impacts outcomes such as the outbreak or extinction of the disease in this case.
Evan Milliken
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Linear Time Local Approximation Algorithm for Maximum Stable Marriage
Algorithms, 2013 We consider a two-sided market under incomplete preference lists with ties, where the goal is to find a maximum size stable matching. The problem is APX-hard, and a 3/2-approximation was given by McDermid [1]. This algorithm has a non-linear running time,
Zoltán Király
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Estimation of local time-varying reproduction numbers in noisy surveillance data. [PDF]
Philos Trans A Math Phys Eng Sci, 2022 Li W +4 more
europepmc +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Waveform-matching reverse time migration for local earthquakesKey points
Earthquake ScienceWith the increasing use of passive seismic data, developing seismic reflection imaging methods based on passive data is of considerable practical significance.
Lanshu Bai, Qingju Wu, Ruiqing Zhang
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Biomedical Signals Local Maxims Detection Using Time Frequency Transforms [PDF]
Journal of Electrical and Electronics Engineering, 2009 The wealth of genomic data currentlyavailable in online databases has caused a need fornew algorithms and analysis techniques to interpretgenomic data.
Reiz Romulus, Gordan Cornelia
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