Results 61 to 70 of about 26,442 (265)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Localization of Universal Problems. Local Colimits [PDF]
Applied Categorical Structures, 2002 Let \({\mathcal A}\) be a category and \({\mathcal B}\), \({\mathcal B}'\) two full subcategories of \({\mathcal A}\). An \({\mathcal A}\)-cylinder from \({\mathcal B}\) to \({\mathcal B}'\) is a couple \((F,f)\) of a map \(F:\text{Obj}({\mathcal B})\to \text{Obj} ({\mathcal B}')\) and a map \(f:\text{Obj}({\mathcal B})\to \text{Mor} ({\mathcal B ...
openaire +3 more sources
ENJEUX ET DÉFIS DE LA DÉCENTRALISATION ET GOUVERNANCE LOCALE AU TOGO : CAS DES TROIS COMMUNES DE LA PREFECTURE DE DOUFELGOU [PDF]
Ziglôbitha, 2022 Résumé : Au début des années 90, la décentralisation prônée par les agences de coopération internationale connaît un regain d’intérêt. Dans la plupart des pays de l’Afrique de l’Ouest, elle traverse des difficultés dans sa mise en application.
Assindah MAGNETINE, Kékessi Kossi ABOSSE & Kpadakpa TEWALAMBA
doaj
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Les facteurs de variation des performances laitières de la chèvre locale dans les zones arides
Journal of Agriculture and Environment for International Development, 2011 Dans les zones arides tunisiennes, les performances laitières de la chèvre locale synthétisent les capacités génétiques de la population et l’impact des facteurs naturels difficiles.
Ilyes Mekki +2 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland.
Gloria Manzotti +5 more
doaj +1 more source