Results 61 to 70 of about 26,603 (266)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Localization of Universal Problems. Local Colimits [PDF]
Applied Categorical Structures, 2002 Let \({\mathcal A}\) be a category and \({\mathcal B}\), \({\mathcal B}'\) two full subcategories of \({\mathcal A}\). An \({\mathcal A}\)-cylinder from \({\mathcal B}\) to \({\mathcal B}'\) is a couple \((F,f)\) of a map \(F:\text{Obj}({\mathcal B})\to \text{Obj} ({\mathcal B}')\) and a map \(f:\text{Obj}({\mathcal B})\to \text{Mor} ({\mathcal B ...
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Les facteurs de variation des performances laitières de la chèvre locale dans les zones arides
Journal of Agriculture and Environment for International Development, 2011 Dans les zones arides tunisiennes, les performances laitières de la chèvre locale synthétisent les capacités génétiques de la population et l’impact des facteurs naturels difficiles.
Ilyes Mekki +2 more
doaj +1 more source
ENJEUX ET DÉFIS DE LA DÉCENTRALISATION ET GOUVERNANCE LOCALE AU TOGO : CAS DES TROIS COMMUNES DE LA PREFECTURE DE DOUFELGOU [PDF]
Ziglôbitha, 2022 Résumé : Au début des années 90, la décentralisation prônée par les agences de coopération internationale connaît un regain d’intérêt. Dans la plupart des pays de l’Afrique de l’Ouest, elle traverse des difficultés dans sa mise en application.
Assindah MAGNETINE, Kékessi Kossi ABOSSE & Kpadakpa TEWALAMBA
doaj
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland.
Gloria Manzotti +5 more
doaj +1 more source