Results 51 to 60 of about 26,603 (266)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Germ cell tumors (GCTs) often arise in the ovaries and testes (extracranial) but can also develop in the brain (intracranial). We examined the relationship of individual, family, and community‐level socioeconomic status (SES) with stage of disease at diagnosis in a cohort of pediatric patients with GCT from Children's Oncology Group
Heydon K. Kaddas +7 more
wiley +1 more source
Local Councillors: Between Local ‘Government’ and Local ‘Governance’ [PDF]
Public Administration, 2001 With a two‐dimensional concept of ‘New Public Management’ as its point of departure, the article points to the development of a specific Danish model of NPM at the local level of government. In the municipalities the market‐oriented NPM dimension has been almost absent and the managerial dimension has been interpreted and translated into a ‘governance’‐
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier +11 more
wiley +1 more source
Optic Nerve Ultrasound Evaluation in Children: A Review
Diagnostics, 2023 Managing patients with neurocritical illness requires monitoring and treating elevated intracranial pressure (ICP), especially in cases in children. In terms of precise and real-time measurements, invasive ICP measurements are presently the gold standard
Giulia Abbinante +5 more
doaj +1 more source
The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature
Pediatric Blood &Cancer, EarlyView.ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi +7 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Timely cancer diagnosis in children and adolescents is important to improving outcomes. We aimed to quantify time to diagnosis and assess variations by patient, demographic and system‐level factors. Procedure We conducted a population‐based study of individuals aged 0–19 years diagnosed with one of 12 cancers from 2010 to 2022 in ...
Callum Mullen +5 more
wiley +1 more source
, 2015 We reduce non-deterministic time $T \ge 2^n$ to a 3SAT instance $ϕ$ of quasilinear size $|ϕ| = T \cdot \log^{O(1)} T$ such that there is an explicit circuit $C$ that on input an index $i$ of $\log |ϕ|$ bits outputs the $i$th clause, and each output bit of $C$ depends on $O(1)$ input bits. The previous best result was $C$ in NC$^1$.
Hamidreza Jahanjou +2 more
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Lignification and Oxidative Enzymes: Localization, Localization, Localization! [PDF]
Plant Physiology, 2020 Lignification of cell walls is a pivotal process in plant life. Lignin is a biopolymer that provides additional stability to secondary cell walls (SCWs), enables vascular cells to transport water, and protects the plant from pathogenic attack ([Tobimatsu and Schuetz, 2019][1]).
openaire +3 more sources