Results 51 to 60 of about 26,442 (265)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Local Councillors: Between Local ‘Government’ and Local ‘Governance’ [PDF]
Public Administration, 2001 With a two‐dimensional concept of ‘New Public Management’ as its point of departure, the article points to the development of a specific Danish model of NPM at the local level of government. In the municipalities the market‐oriented NPM dimension has been almost absent and the managerial dimension has been interpreted and translated into a ‘governance’‐
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Optic Nerve Ultrasound Evaluation in Children: A Review
Diagnostics, 2023 Managing patients with neurocritical illness requires monitoring and treating elevated intracranial pressure (ICP), especially in cases in children. In terms of precise and real-time measurements, invasive ICP measurements are presently the gold standard
Giulia Abbinante +5 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2015 We reduce non-deterministic time $T \ge 2^n$ to a 3SAT instance $ϕ$ of quasilinear size $|ϕ| = T \cdot \log^{O(1)} T$ such that there is an explicit circuit $C$ that on input an index $i$ of $\log |ϕ|$ bits outputs the $i$th clause, and each output bit of $C$ depends on $O(1)$ input bits. The previous best result was $C$ in NC$^1$.
Hamidreza Jahanjou +2 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Lignification and Oxidative Enzymes: Localization, Localization, Localization! [PDF]
Plant Physiology, 2020 Lignification of cell walls is a pivotal process in plant life. Lignin is a biopolymer that provides additional stability to secondary cell walls (SCWs), enables vascular cells to transport water, and protects the plant from pathogenic attack ([Tobimatsu and Schuetz, 2019][1]).
openaire +3 more sources