Results 81 to 90 of about 519,807 (275)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland.
Gloria Manzotti +5 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
La geografía regional: tradiciones y perspectivas contemporáneas
Investigaciones Geográficas, 2007 El conocimiento sobre las trayectorias y direcciones que ha seguido la geografía regional en sus más de dos siglos de existencia, reviste importancia en momentos en donde el pensamiento regional carece de una visión única y alterna con una gran variedad ...
Blanca Rebeca Ramírez
doaj
Higher-order Representation and Reasoning for Automated Ontology Evolution [PDF]
, 2010 : The GALILEO system aims at realising automated ontology evolution. This is necessary to enable intelligent agents to manipulate their own knowledge autonomously and thus reason and communicate effectively in open, dynamic digital environments ...
Bundy, Alan, Chan, M., Lehmann, J.
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
CDKN2A deletion is associated with immune desertification in diffuse pleural mesothelioma
Journal of Experimental & Clinical Cancer ResearchIntroduction Diffuse Pleural Mesothelioma (DPM) is a rare and incurable cancer. Immune checkpoint inhibitors (ICIs) marked some advances but only for a limited fraction of patients.
Federica Torricelli +14 more
doaj +1 more source
Annali dell'Istituto Superiore di Sanità, 2011 The association between cancer incidence and the residence near polluting facilities in an industrial area nearby Taranto has been investigated. Age, sex and occupational exposure were controlled as confounding variables in a case-control study (658 ...
Alessandro Marinaccio +10 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
From Statehouse to Schoolhouse: Anti-Bullying Policy Efforts in U.S. States and School Districts [PDF]
, 2015 In 2011, 29.5 percent of U.S. public school districts didn't have anti-bullying policies, including many districts in states that require them, according to a report published by GLSEN.
Emily A. Greytak +2 more
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