Results 121 to 130 of about 1,706,702 (287)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Localizing Global Standards in Toba, Indonesia Through a Tourist-Centric Perspective On UNESCO Guidelines

Forum Geografi
This study examines the response to and support of the UNESCO recommendations on behalf of geo-tourism using the actual perspectives of tourists visiting the Toba region. The study employed a detailed map of Toba Geo-tourism in the Sumatra Utara Province, Indonesia, so as to provide a comprehensive understanding.
Rachmat Mulyana, I Wayan Koko Suryawan, Iva Yenis Septiariva, Sapta Suhardono, Mega Mutiara Sari, Nova Ulhasanah, Nur Novilina Arifianningsih, Wisnu Prayogo, Dwinto Martri Aji Buana   +8 more
openaire   +2 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Application of deep learning technology in breast cancer: a systematic review of segmentation, detection, and classification approaches

BioMedical Engineering OnLine
Objective To provide a critical and clinically oriented synthesis of recent deep learning developments for breast cancer imaging across major modalities, with emphasis on model architectures, dataset characteristics, methodological quality, and ...
Shuo Gao, Jia Liu, Linqian Li, Di Yang, Yafei Miao, Xu Zhang, Qianqian Han, Yasong Shi, Jianguo Wu, Ke Zhang   +9 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Development of Multi-Objective Particle Swarm Optimisation (MOPSO) strategy in enhancing interference mitigation in Machine-to-Machine (M2M) communication based on fault clearance and communication delay in Smart Grid Networks

Journal of King Saud University: Engineering Sciences
The proliferation of connected devices has led to a paradigm shift in cellular standards, typified by the long-term evolution (LTE) standard. The fifth-generation (5G) standard supportsnumerouspromising mobile technologies, including Machine-to-Machine ...
Ahmed Danasabe Suleiman, Abubabakar Saddiq Mohammmed, Bala Alhaji Salihu, Michael David, Abdullahi Ibrahim Mohammed, Ephraim Michael   +5 more
doaj   +1 more source

Research, Analysis and Insight into National Standards (RAINS) Project. Second Report: Understanding New Zealand’s Very Local National Standards [PDF]

, 2013
This is the second report of the Research, Analysis and Insight into National Standards (RAINS) project, a three-year study of the introduction of National Standards into New Zealand primary and intermediate ...
Thrupp, Martin
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source