Results 131 to 140 of about 304,865 (314)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
A view of the locality conditions on vowel harmony, aligning empirical phenomena within phonology with the principles of the Minimalist program.Intro -- Contents -- Series Foreword -- Acknowledgments -- Abbreviations -- 1 What Is Vowel Harmony, How Does ...
Nevins, Andrew., Keyser, Samuel Jay.
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Impact of government policies on MNEs and local organizations environmental initiatives
, 2010 Multinational enterprises (MNEs) are often perceived as the cause of environmental degradation in developing countries. Through the lens of organisational buying behaviour theory, this manuscript examines environmental practices via landscaping ...
Johnston, Wesley J. +2 more
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Ecology and EvolutionBabinskaiidae is an extinct lacewing family, only known from the Cretaceous, of the superfamily Myrmeleontoidea, currently comprising 22 species in 16 genera.
Xiumei Lu +3 more
doaj +1 more source
Breakdown of Bell Factorization from Non-Injective Effective Descriptions
Quantum ReportsViolations of Bell inequalities are commonly interpreted as evidence for nonlocal influences or as constraints on realist descriptions. We show that the failure of Bell-type factorizability arises naturally when observable outcomes are obtained through a
Jérôme Beau
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
High performance Monte Carlo computation for finance risk data analysis [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Finance risk management has been playing an increasingly important role in the finance sector, to analyse finance data and to prevent any potential crisis ...
Zhao, Yu
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
ULC: A File Block Placement and Replacement Protocol to Effectively Exploit
, 2004 In a large client/server cluster system, file blocks are cached in a multi-level storage hierarchy. Existing file block placement and replacement are either conducted on each level of the hierarchy independently, or by applying an LRU policy on more than
Hierarchical Locality In +2 more
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