Results 101 to 110 of about 42,506 (251)

Nonlinear instabilities and extreme wave localization in fiber optics [PDF]

open access: yes, 2011
Modulation instability and the existence of localized soliton structures are central phenomena of nonlinear systems governed by the focusing nonlinear Schrödinger equation such as Bose-Einstein condensates, plasmas and fluids.
Erkintalo, Miro
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Negative frequency waves in optics : control and investigation of their generation and evolution [PDF]

open access: yes, 2015
This thesis is concerned with various methods for the control and investigation of pulse dynamics in a Photonic Crystal Fibre (PCF) and of the radiation driven by a short pulse.
McLenaghan, Joanna Siân
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Dilated convolution neural operator for multiscale partial differential equations [PDF]

open access: yes
This paper introduces a data-driven operator learning method for multiscale partial differential equations, with a particular emphasis on preserving high-frequency information.
Xu, Bo, Zhang, Lei, Liu, Xinliang
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Magnetism of self -ordered and composite nanostructures [PDF]

open access: yes, 2001
Nanostructured magnetic materials (NMM) have attracted much attention recently due to their unique structural and magnetic properties compared to continuous thin films or bulk materials.
Zeng, Hao
core  

Astrocyte heterogeneity in brain metastases

open access: yesMolecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver   +2 more
wiley   +1 more source

Überlagerung von Grundlösungen in der Elastodynamik zur Behandlung der dynamischen Tunnel-Boden-Bauwerk-Interaktion [PDF]

open access: yes, 2010
For the dynamic calculation of a tunnel-soil-structure-interaction in this paper the Finite Element Method (FEM) is coupled with the Integral Transform Method (ITM).
Müller, G.
core  

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