Results 81 to 90 of about 42,506 (251)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Contribuições sobre a utilização de funções de aproximação contínuas no método generalizado de elementos finitos: avaliação em mecânica da fratura [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópólis, 2012.Procedimentos de discretização que promovem o enriquecimento de subespaços de aproximação, para a solução
Torres, Diego Amadeu Furtado
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Numerical simulation of boundary-layer control using MEMS actuation [PDF]
MEMS actuators and their effect on boundary layers is investigated using numerical simulation. The thesis is specifically focussed on jet actuators and their application to the targeted control of turbulent boundary layers.
Lockerby, Duncan A.
core
A Model-Integrated Localized Collocation Meshless Method (Mims) [PDF]
, 2013 A model integrated meshless solver (MIMS) tailored to solve practical large-scale industrial problems is based on robust meshless methods strategies that integrate a native model-based point generation procedures.
Divo, E. +3 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Protein-ligand binding affinities from large-scale quantum mechanical simulations [PDF]
, 2012 The accurate prediction of protein-drug binding affinities is a major aim of computational drug optimisation and development. A quantitative measure of binding affinity is provided by the free energy of binding, and such calculations typically require ...
Fox, Stephen J, Fox, Stephen J.
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On the dynamical behaviours of solitons and rogue waves in mechanical and hydrodynamical systems [PDF]
, 2020 Solitons are spatially localized waves that can propagate without changing their properties, shapes and velocities, even though after their mutual collisions.
鍾偉才, Chung, Wai Choi
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source