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Definitions, 2014 A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. Localized scleroderma typically affects the skin, with formation of patches or lines of thick and unyielding ...
Carolyn A. Bangert +2 more
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Medical Clinics of North America, 1989
Localized scleroderma has no recognized internal organ involvement. It may rarely coexist with a systemic connective tissue disease, but is not thought to progress to systemic sclerosis. Although never fatal, localized scleroderma may cause considerable disability from joint contractures and subcutaneous atrophy.
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Localized scleroderma has no recognized internal organ involvement. It may rarely coexist with a systemic connective tissue disease, but is not thought to progress to systemic sclerosis. Although never fatal, localized scleroderma may cause considerable disability from joint contractures and subcutaneous atrophy.
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Seminars in Cutaneous Medicine and Surgery, 1998
Localized scleroderma can be divided into three main subtypes: morphea, linear scleroderma, and generalized morphea. Plaque morphea usually has a good prognosis. Variants of morphea, including guttate morphea and atrophoderma of Pasini and Pierini, are seen.
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Localized scleroderma can be divided into three main subtypes: morphea, linear scleroderma, and generalized morphea. Plaque morphea usually has a good prognosis. Variants of morphea, including guttate morphea and atrophoderma of Pasini and Pierini, are seen.
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Archives of dermatology, 1975
Familial scleroderma is rare; only seven documented instances of the disease have been reported, to our knowledge. This report adds two more families to the literature. Three children in one family and two in the other had clinically and histiologically established localized scleroderma.
R C, Wuthrich, H H, Roenigk, W D, Steck
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Familial scleroderma is rare; only seven documented instances of the disease have been reported, to our knowledge. This report adds two more families to the literature. Three children in one family and two in the other had clinically and histiologically established localized scleroderma.
R C, Wuthrich, H H, Roenigk, W D, Steck
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Preliminary Evidence on Abatacept Safety and Efficacy in Refractory Juvenile Localized Scleroderma.
Rheumatology, 2020OBJECTIVES To evaluate the safety and efficacy of abatacept treatment for refractory juvenile localized scleroderma (jLS) in a retrospective study. METHODS A multicentre cohort study was performed to evaluate jLS subjects treated with abatacept with ...
Suzanne C. Li +7 more
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Morphea (Localized Scleroderma) in a COVID-19 patient: A Case Report
, 2021Since the COVID-19 pandemic raised all over the world a year ago, many dermatological manifestations have been reported in COVID-19 patients including alopecia areata, erythematous rash, widespread urticaria and chickenpox-like vesicles and Chilblain ...
Capalbo Alessandro +6 more
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British Journal of Dermatology, 2020
Paediatric localized scleroderma (LS) can negatively impact health‐related quality of life (HRQoL) by causing skin fibrosis, abnormal limb development, disfigurement, and side‐effects from immunosuppressive treatment. Studies to date have rarely included
C. Zigler +7 more
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Paediatric localized scleroderma (LS) can negatively impact health‐related quality of life (HRQoL) by causing skin fibrosis, abnormal limb development, disfigurement, and side‐effects from immunosuppressive treatment. Studies to date have rarely included
C. Zigler +7 more
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Dermatologic therapy, 2012
Localized scleroderma (also called morphea) is a term encompassing a spectrum of sclerotic autoimmune diseases that primarily affect the skin, but also might involve underlying structures such as the fat, fascia, muscle, and bones. Its exact pathogenesis is still unknown, but several trigger factors in genetically predisposed individuals might ...
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Localized scleroderma (also called morphea) is a term encompassing a spectrum of sclerotic autoimmune diseases that primarily affect the skin, but also might involve underlying structures such as the fat, fascia, muscle, and bones. Its exact pathogenesis is still unknown, but several trigger factors in genetically predisposed individuals might ...
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Systemic and localized scleroderma
Clinics in Dermatology, 2006Sclerosing conditions of the skin are manifested by a full spectrum of presentations that includes skin-limited forms as well as those which can involve internal organs and result in death. At this point, we are just beginning to understand the mechanisms of tissue fibrosis, and it is likely that the fibrotic processes are a heterogeneous group of ...
Lorinda, Chung +3 more
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Localized and systemic scleroderma
Seminars in Cutaneous Medicine and Surgery, 2001Scleroderma is a broad term encompassing both localized and systemic sclerosis. Localized scleroderma is a cutaneous limited fibrosis that manifests as plaque morphea, generalized morphea, linear scleroderma, and deep morphea. Systemic scleroderma (sclerosis) can manifest as either limited or diffuse disease.
A, Hawk, J C, English
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