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Localized scleroderma – current treatment options
Przegląd Dermatologiczny, 2017 Localized scleroderma (morphea) is a connective tissue disease that affects the skin, subcutaneous tissue and underlying tissues including the fasciae, muscles and bones. The treatment of localized scleroderma depends on the clinical form of the disease,
Katarzyna Wolska-Gawron +2 more
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Localized scleroderma – classification and tools used for the evaluation of tissue damage and disease activity/severity [PDF]
Przegląd Dermatologiczny, 2017 Localized scleroderma is a rare autoimmune disorder affecting the dermis, subcutaneous tissue and deeper structures. The course of localized scleroderma includes three stages: early inflammation, progressive sclerosis and atrophy. The active stage of the
Katarzyna Wolska-Gawron +1 more
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Вопросы современной педиатрии, 2020 The localized scleroderma (morphea) is the clinical option of the juvenile scleroderma, the third in prevalence rheumatic condition in pediatrics. The article summarizes all the data on the classification, diagnostics, and differential diagnosis of ...
Rinat K. Raupov +2 more
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Phosphodiesterase-4 inhibition in localized scleroderma: A case series of topical roflumilast [PDF]
SAGE Open Medical Case ReportsLocalized scleroderma, or morphea, is a chronic fibrosing skin condition with limited therapeutic options, particularly for patients who are elderly, immunocompromized, or intolerant to systemic immunosuppressants.
Ghassan Barnawi +4 more
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High-content Image-based Drug Testing of Patients’ Primary Fibroblasts Reveals Potential New Treatment Options for Localized Scleroderma [PDF]
Acta Dermato-VenereologicaLocalized scleroderma is a rare autoimmune disease characterized by progressive fibrosis of the skin and its underlying structures, causing loss of normal tissue structure and function.
Katariina Mähönen +10 more
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Localized scleroderma: A rare clinical entity
Journal of Indian Academy of Oral Medicine and Radiology, 2014 Localized Scleroderma (LS), which is also referred to as morphea, is an inflammatory disease that leads to diffuse or localized fibrotic and atrophic skin hardening.
Ranjana Garg +2 more
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Detection of autoimmune antibodies in localized scleroderma by synthetic oligonucleotide antigens. [PDF]
PLoS ONE, 2018 In this study, we developed a series of synthetic oligonucleotides that allowed us to investigate the details on the antigen recognition by autoimmune antibodies in localized scleroderma subjects.
Simone Samuelsen +4 more
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Endpoints and outcomes for localized scleroderma/morphea: a scoping literature review [PDF]
Pediatric Rheumatology Online JournalBackground Current treatment for localized scleroderma (LS) has been shown to halt disease activity, but little is still known about patient experiences with these treatments, nor is there consensus about optimal measurement strategies for future ...
Alexy Hernandez +5 more
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Localized Scleroderma, Systemic Sclerosis and Cardiovascular Risk: A Danish Nationwide Cohort Study [PDF]
Acta Dermato-Venereologica, 2017 Recent findings indicate that patients with systemic sclerosis have an increased risk of cardiovascular disease. To determine whether patients with systemic sclerosis or localized scleroderma are at increased risk of cardiovascular disease, a cohort ...
Jeanette Halskou Hesselvig +5 more
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Current Opinion in Rheumatology, 2006 PURPOSE OF REVIEW: Localized scleroderma, also known as morphoea, has a variety of clinical manifestations that can include systemic involvement. Early recognition, diagnosis and treatment may improve the long-term outcome.
Laxer R. M., Zulian F.
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