Results 191 to 200 of about 8,380,026 (270)

Surgical Debulking Modifies Notch Signaling and May Improve Vismodegib Effectiveness for Locally Advanced Basal Cell Carcinoma. [PDF]

JID Innov
Maglakelidze N, Gettle SL, Longenecker AL, Vidimos AT, Billingsley EM, Hobbs RP, Lam C.   +6 more
europepmc   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Interim analysis of the multinational, post-authorization safety study (NISSO) to assess the long-term safety of sonidegib in patients with locally advanced basal cell carcinoma. [PDF]

BMC Cancer
Gutzmer R, Leiter U, Mohr P, Kähler KC, Ascierto PA, Scalvenzi M, Peris K, Pérez-Pastor GM, Fernández-de-Misa R, Botella-Estrada R, Hunger RE, Martelli S, Güneli N, Arntz R, Hauschild A.   +14 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Low-Dose Vismodegib as Maintenance Therapy After Locally Advanced Basal Cell Carcinoma Complete Remission: High Efficacy with Minimal Toxicity. [PDF]

Dermatol Ther (Heidelb), 2020
Scalvenzi M, Cappello M, Costa C, Fabbrocini G, Luciano M, Villani A.   +5 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Prognostic Value of Combined FDG PET and MRI Analysis of Cervical Cancer: A Systematic Review and Meta‐Analysis

Journal of Medical Radiation Sciences, EarlyView.
This systematic review and meta‐analysis synthesised FDG PET/MRWE biomarkers in cervical cancer, including a pooled analysis of the association between metabolic activity (SUV‐based metrics) and tumour diffusion characteristics (ADC measures). Prognostic evidence from the included studies was also analysed to identify PET‐ and MRI‐based parameters, as ...
William Wei, Dominic Ku, Natalie Rutherford   +2 more
wiley   +1 more source

Efficiency of long-term high-dose intravenous ascorbic acid therapy in locally advanced basal cell carcinoma - a pilot study. [PDF]

Postepy Dermatol Alergol, 2020
Bánvölgyi A, Lőrincz K, Kiss N, Avci P, Fésűs L, Szipőcs R, Krenács T, Gyöngyösi N, Wikonkál N, Kárpáti S, Németh K.   +10 more
europepmc   +1 more source

StrataXRT Versus Mepitel Film for Prevention of Acute Radiation Dermatitis in Postmastectomy Radiotherapy: A Pooled Analysis of Intra‐Patient Randomised Trials

Journal of Medical Radiation Sciences, EarlyView.
In 120 patients receiving postmastectomy radiotherapy, each irradiated chest wall was divided into medial and lateral halves, which were randomised to Mepitel Film or StrataXRT. Mepitel Film reduced grade 2–3 acute radiation dermatitis and clinician‐assessed erythema and moist desquamation over time.
Shing Fung Lee, Patries M. Herst, Melissa L. James, Pui Lam Yip, Carminia Lapuz, Farshad Foroudi, Michael Chao   +6 more
wiley   +1 more source

Optimising hypoxia PET imaging and its applications in guiding targeted radiation therapy for non‐small cell lung cancer: a scoping review

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 106-118, March 2025.
This review article reports that quantification of hypoxic volumes using PET in the pre‐radiation therapy setting is of prognostic value and indicative of treatment response in non‐small cell lung cancer. Abstract Introduction Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death. Definitive treatment includes chemotherapy and
Carol Marks, Michelle Leech
wiley   +1 more source