Results 41 to 50 of about 402 (270)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Bounds on Binary Locally Repairable Codes Tolerating Multiple Erasures

open access: yes, 2018
Recently, locally repairable codes have gained significant interest for their potential applications in distributed storage systems. However, most constructions in existence are over fields with size that grows with the number of servers, which makes the
Grezet, Matthias   +4 more
core   +1 more source

Additive Manufacturing of Continuous Fibre Reinforced Composites: Process, Characterisation, Modelling, and Sustainability

open access: yesAdvanced Engineering Materials, EarlyView.
Additive manufacturing provides precise control over the placement of continuous fibres within polymer matrices, enabling customised mechanical performance in composite components. This article explores processing strategies, mechanical testing, and modelling approaches for additive manufactured continuous fibre‐reinforced composites.
Cherian Thomas, Amir Hosein Sakhaei
wiley   +1 more source

PASTA‐ELN: Simplifying Research Data Management for Experimental Materials Science

open access: yesAdvanced Engineering Materials, EarlyView.
Research data management faces ongoing hurdles as many ELNs remain complex and restrictive. PASTA‐ELN offers an open‐source, cross‐platform solution that prioritizes simplicity, offline access, and user control. Its in tuitive folder structure, modular Python add‐ons, and open formats enable seamless documentation, FAIR data practices, and easy ...
S. Brinckmann, G. Winkens, R. Schwaiger
wiley   +1 more source

Upper bounds on maximum lengths of Singleton-optimal locally repairable codes

open access: yes, 2022
A locally repairable code is called Singleton-optimal if it achieves the Singleton-type bound. Such codes are of great theoretic interest in the study of locally repairable codes.
Wu, Tingyi   +3 more
core  

3D Printing Innovations in Polymeric Porous and Patterned Architecture

open access: yesAdvanced Functional Materials, EarlyView.
Polymeric foams occupy a unique structural space between dense solids and open networks, where engineered void fraction governs mechanical compliance, thermal resistance, and mass transport. Additive manufacturing now enables precise spatial control over cellular architecture, unlocking designer foam structures across applications spanning crash ...
Dhanush Patil   +13 more
wiley   +1 more source

Localitycache: Toward efficient straggler tolerance in LRC-coded storage via caching local parity blocks

open access: yesHigh-Confidence Computing
Modern distributed storage systems increasingly employ Locally Repairable Codes (LRCs) to provide reliable, low-cost data storage with high repair efficiency.
Ximeng Chen, Si Wu, Yinlong Xu
doaj   +1 more source

On the Combinatorics of Locally Repairable Codes via Matroid Theory

open access: yes, 2016
This paper provides a link between matroid theory and locally repairable codes (LRCs) that are either linear or more generally almost affine. Using this link, new results on both LRCs and matroid theory are derived.
Westerbäck, Thomas,   +7 more
core   +1 more source

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