Results 101 to 110 of about 2,642,270 (309)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

IRS II: a framework and infrastructure for semantic web services [PDF]

, 2003
In this paper we describe IRS–II (Internet Reasoning Service) a framework and implemented infrastructure, whose main goal is to support the publication, location, composition and execution of heterogeneous web services, augmented with semantic ...
Cabral, Liliana, Domingue, John, Gaspari, Mauro, Motta, Enrico   +3 more
core   +2 more sources

Rethinking Location Privacy for Unknown Mobility Behaviors

, 2019
Location Privacy-Preserving Mechanisms (LPPMs) in the literature largely consider that users' data available for training wholly characterizes their mobility patterns.
Oya, Simon, Pérez-González, Fernando, Troncoso, Carmela   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Detecting Themed Streets Using a Location Based Service Application

ISPRS International Journal of Geo-Information, 2016
Various themed streets have recently been developed by local governments in order to stimulate local economies and to establish the identity of the corresponding places.
Byeongsuk Ji, Youngmin Lee, Kiyun Yu, Pil Kwon   +3 more
doaj   +1 more source

Next-Generation EU DataGrid Data Management Services

, 2003
We describe the architecture and initial implementation of the next-generation of Grid Data Management Middleware in the EU DataGrid (EDG) project. The new architecture stems out of our experience and the users requirements gathered during the two ...
Akos Frohner, David Cameron, Diana Bosio, Domenici A, Erwin Laure, Federico Dicarlo, Floriano Zini, Gavin Mccance, Gianluca Volpato, Heinz Stockinger, Joni Hahkala, Kurt Stockinger, Leanne Guy, Levi Lucio, Livio Salconi, Mika Sil, Niklas Karlsson, Olle Mulmo, Paul Millar, Peter Kunszt, Ruben Carvajal-Schiaffino, Sophie Lemaitre, Ville Nenonen, William Bell   +23 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Development of Mobile GIS Based Digital Map Location Marking Application for Navigation Purposes

JISA (Jurnal Informatika dan Sains)
In today's digital era, map and navigation applications have become essential tools for users to find locations, obtain the fastest routes, and explore new places.
Alif Ghifari, Sutarman Sutarman
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source