Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Modular multilevel converter (MMC), which is highly modular, easy to be expanded, and has good output voltage waveform, is especially suitable for medium and high voltage power system applications.
Bo Xu, Cui Li, Huipeng Li, Ruchun Ding
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Human papillomavirus (HPV) 16 infection initiates upon viral entry into the basal cells of the epithelium. The virus manipulates signaling pathways to complete its life cycle, which depends on cellular differentiation.
Mariano A. Molina +3 more
doaj +1 more source
Remote working in academia: a site of contested identities. [PDF]
This development paper discusses the affects and impact of formalised remote (location-independent) working on notions and construction of academic identity. Data is drawn from a six year longitudinal ethnographic study exploring the lived experiences of
Lee, Amanda
core +1 more source
Efficient Batch Update of Unique Identifiers in a Distributed Hash Table for Resources in a Mobile Host [PDF]
Resources in a distributed system can be identified using identifiers based on random numbers. When using a distributed hash table to resolve such identifiers to network locations, the straightforward approach is to store the network location directly in
Chung, Yoo
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
CRACK LOCALIZATION IN HYDRAULIC TURBINE BLADES BASED ON KERNEL INDEPENDENT COMPONENT ANALYSIS AND WAVELET NEURAL NETWORK [PDF]
Hydraulic turbine runner has a complex structure, and traditional location methods can't meet its requirement. This paper describes a source location of cracks in turbine blades by combining kernel independent component analysis (KICA) with wavelet ...
Xianghong Wang +3 more
doaj +1 more source
A Scalable Location Service for Distributed Objects [PDF]
We describe a service for locating distributed objects using location-independent object identifiers. An object in our model is physically distributed, with multiple copies simultaneously active on different machines.
Hauck, F.J. +2 more
core +6 more sources
Towards an Efficient Context-Aware System: Problems and Suggestions to Reduce Energy Consumption in Mobile Devices [PDF]
Looking for optimizing the battery consumption is an open issue, and we think it is feasible if we analyze the battery consumption behavior of a typical context-aware application to reduce context-aware operations at runtime.
Ardito, Luca +3 more
core +1 more source

