Results 81 to 90 of about 1,124,248 (287)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Analysis of Relationship Between Personality and Favorite Places with Poisson Regression Analysis

ITM Web of Conferences, 2018
A relationship between human personality and preferred locations have been a long conjecture for human mobility research. In this paper, we analyzed the relationship between personality and visiting place with Poisson Regression.
Yoon Song Ha, Baek Kang Hwa
doaj   +1 more source

A Peer-to-Peer Middleware Framework for Resilient Persistent Programming [PDF]

, 2010
The persistent programming systems of the 1980s offered a programming model that integrated computation and long-term storage. In these systems, reliable applications could be engineered without requiring the programmer to write translation code to ...
Dearle, Alan, Kirby, Graham, McCarthy, Andrew, Norcross, Stuart   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

An active, ontology-driven network service for Internet collaboration

, 2004
Web portals have emerged as an important means of collaboration on the WWW, and the integration of ontologies promises to make them more accurate in how they serve users’ collaboration and information location requirements.
Courtenage, Simon, Feeney, Kevin, Lewis, David, Tiropanis, Thanassis   +3 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Bridging Perspectives, Building Resilience: Safety-II Guided Reflexive Dialogues Between Care Professionals and Clients as Part of Developing Integrated Maternity Care

International Journal of Integrated Care
Background: Limitations of traditional structures and approaches to further enhance patient safety, satisfaction, and systemic sustainability in healthcare, are becoming increasingly visible.
Sarah R. Lips, Jolanda C. G. Boxem-Tiemessen, Anna M. Ligthart, Tjerk Jan Schuitmaker-Warnaar, Martine C. de Bruijne, Corine J. M. Verhoeven, Petra Verdonk, Ank de Jonge   +7 more
doaj   +1 more source

Location Sensitive Deep Convolutional Neural Networks for Segmentation of White Matter Hyperintensities

Scientific Reports, 2017
The anatomical location of imaging features is of crucial importance for accurate diagnosis in many medical tasks. Convolutional neural networks (CNN) have had huge successes in computer vision, but they lack the natural ability to incorporate the ...
Mohsen Ghafoorian, Nico Karssemeijer, Tom Heskes, Inge W. M. van Uden, Clara I. Sanchez, Geert Litjens, Frank-Erik de Leeuw, Bram van Ginneken, Elena Marchiori, Bram Platel   +9 more
doaj   +1 more source

Race, tumor location, and disease progression among low‐risk prostate cancer patients

Cancer Medicine, 2020
Background The relationship between race, prostate tumor location, and BCR‐free survival is inconclusive. This study examined the independent and joint roles of patient race and tumor location on biochemical recurrence‐free (BCR) survival.
Justin G. Mygatt, Jennifer Cullen, Samantha A. Streicher, Huai‐Ching Kuo, Yongmei Chen, Denise Young, William Gesztes, Grant Williams, Galen Conti, Christopher Porter, Sean P. Stroup, Kevin R. Rice, Inger L. Rosner, Allen Burke, Isabell Sesterhenn   +14 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source