Results 81 to 90 of about 5,564,905 (298)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Wave-Speed-Independent Traveling Wave Fault Location Method for Flexible DC Transmission Lines

Energies
Accurate fault location in flexible DC transmission lines is essential for ensuring rapid fault clearance and system reliability. However, traditional traveling-wave methods are often affected by wave velocity variations and synchronization errors.
Huina Hong, Zhiwei Cheng, Hongyi Yang, Kaixin Zhang, Shenxing Shi, Wenjing Zhang, Zhiwei Zhuo, Weifeng Dong   +7 more
doaj   +1 more source

Location Sensitive Deep Convolutional Neural Networks for Segmentation of White Matter Hyperintensities

Scientific Reports, 2017
The anatomical location of imaging features is of crucial importance for accurate diagnosis in many medical tasks. Convolutional neural networks (CNN) have had huge successes in computer vision, but they lack the natural ability to incorporate the ...
Mohsen Ghafoorian, Nico Karssemeijer, Tom Heskes, Inge W. M. van Uden, Clara I. Sanchez, Geert Litjens, Frank-Erik de Leeuw, Bram van Ginneken, Elena Marchiori, Bram Platel   +9 more
doaj   +1 more source

Privacy through uncertainty in location-based services [PDF]

, 2013
Location-Based Services (LBS) are becoming more prevalent. While there are many benefits, there are also real privacy risks. People are unwilling to give up the benefits - but can we reduce privacy risks without giving up on LBS entirely?
Kuijpers, Bart, Othman, Walied, Shawn Merrill, Erik Buchmann, Walied Othman, Erkay Savas, Basalp, Nilguen, Biskup, Joachim, Clifton, Chris, Savaş, Erkay, Başalp, Nilgün, Buchmann, Erik, Joachim Biskup, Bart Kuijpers, Nilgun Basalp, Chris Clifton, Merrill, Shawn   +16 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Location- and feature-based selection histories make independent, qualitatively distinct contributions to urgent visuomotor performance

eLife
Attention mechanisms guide visuomotor behavior by weighing physical salience and internal goals to prioritize stimuli as choices for action. Although less well studied, selection history, which reflects multiple facets of experience with recent events ...
Emily E Oor, Emilio Salinas, Terrence R Stanford   +2 more
doaj   +1 more source

Race, tumor location, and disease progression among low‐risk prostate cancer patients

Cancer Medicine, 2020
Background The relationship between race, prostate tumor location, and BCR‐free survival is inconclusive. This study examined the independent and joint roles of patient race and tumor location on biochemical recurrence‐free (BCR) survival.
Justin G. Mygatt, Jennifer Cullen, Samantha A. Streicher, Huai‐Ching Kuo, Yongmei Chen, Denise Young, William Gesztes, Grant Williams, Galen Conti, Christopher Porter, Sean P. Stroup, Kevin R. Rice, Inger L. Rosner, Allen Burke, Isabell Sesterhenn   +14 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Smartphone-Based Body Location-Independent Functional Mobility Analysis in Patients with Parkinson's Disease: A Step towards Precise Medicine. [PDF]

J Pers Med, 2022
Vila-Viçosa D, Leitão M, Bouça-Machado R, Pona-Ferreira F, Alberto S, Ferreira JJ, Matias R.   +6 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source